Study on the Toxicological Impacts of Intraperitoneal Microcystin-LR Injection on GIFT Tilapia (Oreochromis niloticus) Through Multi-Omics Analysis

文献类型： 外文期刊

第一作者： Wu, Haizheng

作者： Wu, Haizheng;Du, Jinliang;Cao, Liping;Xu, Gangchun;Zhu, Haojun;Li, Quanjie;Gao, Jiancao;Du, Jinliang;Cao, Liping;Sun, Yi;Xu, Gangchun

作者机构：

关键词： microcystin-LR; GIFT tilapia; oxidative stress; intestinal microbiota; SCFAs

期刊名称：ANTIOXIDANTS （ 影响因子：6.6； 五年影响因子：7.3 ）

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年卷期： 2025 年 14 卷 3 期

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收录情况： SCI

摘要： This study employed multi-omics analysis to systematically evaluate the toxic effects of intraperitoneal injection of MC-LR on GIFT tilapia. The results showed that 96 h post injection, serum levels of aspartate GOT, GPT, LYZ, T-AOC, and SOD significantly decreased (p < 0.05). In contrast, hepatic levels of CAT and MDA significantly increased. The 16S rDNA sequencing method revealed a significant reduction in the alpha diversity of the intestinal microbiota. At the phylum level, the relative abundances of Firmicutes and Bacteroidota significantly decreased; at the genus level, several genera, including Bacteroides and Pseudomonas, also exhibited significant changes. Functional prediction indicated that the affected pathways were primarily related to metabolism and disease. Additionally, targeted metabolomics analysis showed a significant decrease in the levels of several SCFAs, such as butyric acid. Correlation analysis further elucidated the complex interactions between the intestinal microbiota, biochemical indicators, and SCFA metabolism. Overall, the study demonstrated that MC-LR induced oxidative stress and liver damage and led to intestinal microbiota imbalance and metabolic dysfunction in GIFT tilapia.

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