Enhanced bone regeneration using poly(trimethylene carbonate)/vancomycin hydrochloride porous microsphere scaffolds in presence of the silane coupling agent modified hydroxyapatite nanoparticles

文献类型： 外文期刊

第一作者： He, Jian

作者： He, Jian;Liang, Gaofeng;Hu, Xulin;Xing, Luyao;Chen, Dongliang;Xiong, Chengdong;Zhang, Lifang;Zhang, Xiangchun;Peng, Lijun

作者机构：

关键词： Porous microspheres; Modified hydroxyapatite nanoparticles (KHA NPs); Vancomycin hydrochloride; Inflammation response

期刊名称：JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY （ 影响因子：6.064； 五年影响因子：5.914 ）

ISSN： 1226-086X

年卷期： 2021 年 99 卷

页码：

收录情况： SCI

摘要： Tissue-engineered scaffolds acted as active natural extracellular matrices that allowed for cell attachment, migration, proliferation, and differentiation. To enhance the drug loading, degradation control, and mechanical features of tissue-engineered scaffolds used in bone regeneration applications, we synthesized novel poly(trimethylene carbonate) (PTMC)/modified HA nanoparticles (KHA NPs, modified by silane coupling agent)/vancomycin hydrochloride (VH) porous microspheres scaffold. The fabricated PTMC/KHA/VH scaffold has unique surface corrosion degradation, excellent surface properties, and high cytocompatibility. The novel PTMC/KHA/VH scaffold was characterized by 42% porosity, 100 mm pore size, and 208.2 MPa compressive modulus. After the treatment of a rat femur defect for 4, 8, and 12 weeks, the surface corrosion biodegraded of the PTMC/KHA/VH scaffold remarkably decreased inflammation response and promoted bone regeneration, suggesting its use as a bioactive structure in bone tissue engineering. (C) 2021 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V. All rights reserved.

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