Comparison of Different Methods for Extracting the Astaxanthin from Haematococcus pluvialis: Chemical Composition and Biological Activity

文献类型： 外文期刊

第一作者： Tan, Yicheng

作者： Tan, Yicheng;Ye, Zhang;Tan, Xinghe;Liu, Zhiwei;Wang, Mansheng;Manzoor, Muhammad Faisal;Aadil, Rana Muhammad

作者机构：

关键词： Heamatococcus pluvialis; astaxanthin; cell disruption techniques; antioxidant activities; anti-proliferative ability

期刊名称：MOLECULES （ 影响因子：4.412； 五年影响因子：4.588 ）

ISSN：

年卷期： 2021 年 26 卷 12 期

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收录情况： SCI

摘要： In this study, the impact of different cell disruption techniques (high-pressure micro fluidization (HPMF), ionic liquids (ILs), multi-enzyme (ME), and hydrochloric acid (HCl)) on the chemical composition and biological activity of astaxanthin (AST) obtained from Haematococcus pluvialis was investigated. Results indicated that all cell disruption techniques had a significant effect on AST composition, which were confirmed by TLC and UPC2 analysis. AST recovery from HCl (HCl-AST) and ILs (ILs-AST) cell disruption techniques was dominant by free and monoesters AST, while AST recovery from HPMF (HPMF-AST) and ME (ME-AST) cell disruption techniques was composed of monoesters, diesters, and free AST. Further biological activity analysis displayed that HCl-AST showed the highest ABTS and DPPH activity, while ILs-AST showed better results against the ORAC assay. Additionally, ILs-AST exhibits a stronger anti-proliferation of HepG2 cells in a dose-dependent manner, which was ascribed to AST-induced ROS in to inhibit the proliferative of cancer cells.

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