A Novel •OH-Monitor ER-Targeted Probe to Expose the Function of Sorafenib

文献类型： 外文期刊

第一作者： Kong, Lingyu

作者： Kong, Lingyu;Zhao, Manfen;Liu, Jianfei;Ye, Yong;Kong, Lingyu;Zhao, Manfen;Liu, Jianfei;Ye, Yong;Zhu, Xiaofei;Zhang, Di

作者机构：

关键词： Hydroxyl radical; Ferroptosis; Endoplasmic reticulum stress; Cancer treatment

期刊名称：CHEMISTRY-AN ASIAN JOURNAL （ 影响因子：3.3； 五年影响因子：3.4 ）

ISSN： 1861-4728

年卷期： 2024 年 19 卷 24 期

页码：

收录情况： SCI

摘要： The hydroxyl radical (center dot OH), widely recognized as the most potent free radical, plays a crucial role in numerous physiological and pathological pathways due to its strong oxidizability-Ferroptosis, as a novel mode of cell death, is initiated by the accumulation of iron-dependent lipid peroxidation. Among them, center dot OH as the original reactive oxygen species (ROSs)is mass-produced due to Fenton reaction invivo and closely related to cancer treatment-Besides, endoplasmic reticulum (ER) as a membrane-rich structure organelle, is a crucial organelle in all eukaryotes where excessive expression of ROSs, including center dot OH can triggerER stress which was reported thatwasclosely related toferroptosis. So developing a new probe for their interrelationship research is important. In this paper, we constructed a1,8-naphthalimide-based ER-targeted fluorescence probe named M-1 to monitor center dot OH variation invitro and vivo. What's more, we achieved the monitor of center dot OH during ER stress andferroptosis processesin cancer cells, andfurther explored the important role of ER stress and ferroptosis processes in SF (sorafenib) involved cancer cells.

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