Advances in aggregation-induced emission fluorescent probes for reactive sulfur species detection

文献类型： 外文期刊

第一作者： Zhang, Qianqian

作者： Zhang, Qianqian;Zhang, Zezhi;Liu, Jin;Song, Ajuan;Li, Chengwei;Yang, Xiaopeng;Zhang, Di;Ye, Yong

作者机构：

关键词： Fluorescent probe; Aggregation-induced emission; Reactive Sulfur species; Detection

期刊名称：COORDINATION CHEMISTRY REVIEWS （ 影响因子：23.5； 五年影响因子：22.7 ）

ISSN： 0010-8545

年卷期： 2026 年 547 卷

页码：

收录情况： SCI

摘要： Reactive sulfur species (RSS), including cysteine (Cys), homocysteine (Hcy), glutathione (GSH), hydrogen sulfide (H2S), hydrogen polysulfides (H2Sn), and sulfur dioxide (SO2), play concentration-dependent roles in physiological signaling, environmental homeostasis, and disease pathogenesis. Conventional detection methods lack spatiotemporal resolution for real-time tracking in complex matrices, while traditional fluorescent probes suffer from aggregation-caused quenching (ACQ). Aggregation-induced emission (AIE) probes overcome these limitations by exhibiting fluorescence enhancement upon aggregation through restricted intramolecular motion (RIM), enabling superior photostability, signal-to-noise ratios, and environmental adaptability. This comprehensive review synthesizes recent advances in AIE probe design for RSS detection, focusing on molecular strategies, such as nucleophilic addition, cleavage reactions, disulfide exchange, and metal-complex displacement, that achieve ultrasensitivity and selectivity. We highlight transformative applications in real-time RSS imaging within live cells, organelles (mitochondria, lysosomes), disease models, environmental monitoring, and food safety. Persistent challenges in absolute specificity, quantitative in vivo analysis, and clinical translation are critically evaluated, with perspectives on next-generation biocompatible materials, multimodal probes, and point-of-care diagnostics.

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