Goose IRF7 is involved in antivirus innate immunity by mediating IFN activation
文献类型: 外文期刊
第一作者: Lin, Zhenyu
作者: Lin, Zhenyu;Wang, Jie;Zhao, Shurui;Li, Yanlin;Yan, Yaxian;Cheng, Yuqiang;Sun, Jianhe;Zhang, Yanhe;Wang, Yue
作者机构:
关键词: Goose; Interferon regulatory factor 7; Interferon; Innate immunity; Newcastle disease virus
期刊名称:DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY ( 影响因子:3.605; 五年影响因子:3.833 )
ISSN: 0145-305X
年卷期: 2022 年 133 卷
页码:
收录情况: SCI
摘要: Interferon regulatory factor (IRF) 3 and IRF7 are the most important nuclear transcription factors regulating type-I interferon (IFN) production in mammals and the IRF3 is missing in birds. Our previous study found that IFR7 is the most important IRF in chickens, however, its functions in geese remain unknown. We cloned goose IRF7 (GoIRF7) and conducted bioinformatics analyses to compare the chromosomal location and protein homology of IRF7 in different species. Overexpression of GoIRF7 in DF-1 cells induced the activation of IFN-beta, and this activation correlated positively with the dosage of transfected plasmids. Overexpression of GoIRF7 in goose embryonic fibroblasts (GEFs) induced the expression of IFNs, proinflammatory cytokines, and IFN-stimulated genes (ISGs); it also inhibited replication of Newcastle disease virus (NDV) and vesicular stomatitis virus (VSV). Our results suggest that GoIRF7 is an important regulator of IFNs, proinflammatory cytokines, and ISGs and plays a role in antiviral innate immunity in geese.
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