Population Pharmacokinetics of Enrofloxacin in Micropterus salmoides Based on a Nonlinear Mixed Effect Model After Intravenous and Oral Administration

文献类型： 外文期刊

第一作者： Xu, Ning

作者： Xu, Ning;Zhou, Shun;Dong, Jing;Li, Jiangtao;Ai, Xiaohui;Xu, Ning;Ding, Yongzhen

作者机构：

关键词： enrofloxacin; population pharmacokinetics; statistical approaches; largemouth bass; body weight

期刊名称：ANIMALS （ 影响因子：2.7； 五年影响因子：3.2 ）

ISSN： 2076-2615

年卷期： 2025 年 15 卷 10 期

页码：

收录情况： SCI

摘要： This study aimed to investigate the PPK of EF in largemouth bass after oral and intravenous administration based on a nonlinear mixed effect model. Samples were collected using the sparse sampling method at pre-designed time points determined by high-performance liquid chromatography with a fluorescent detector. The initial PK parameters were estimated by reference search and the calculation of a na & iuml;ve pooled approach. The covariate model included a variation in body weight. The oral dose data were best fitted by a one-compartment model. The injection dose data were best fitted by a two-compartment model. The results demonstrated that body weight had no marked effect on the parameters of PPK. Finally, the bioavailability was calculated to be 12.24%. The area under the concentration-time curve/minimum inhibitory concentration was estimated to be >= 408.16, indicating that EF at 20 mg/kg has high effectiveness for aquatic pathogens.

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