The Expanding Role of Pyridine and Dihydropyridine Scaffolds in Drug Design

文献类型： 外文期刊

第一作者： Ling, Yong

作者： Ling, Yong;Hao, Zhi-You;Liang, Dong;Zhang, Chun-Lei;Zhang, Chun-Lei;Liu, Yan-Fei;Wang, Yan;Wang, Yan

作者机构：

关键词： nitrogen heterocycles; pharmaceuticals; bioactive compounds; current trend; substituent effect

期刊名称：DRUG DESIGN DEVELOPMENT AND THERAPY （ 影响因子：4.162； 五年影响因子：4.278 ）

ISSN： 1177-8881

年卷期： 2021 年 15 卷

页码：

收录情况： SCI

摘要： Pyridine-based ring systems are one of the most extensively used heterocycles in the field of drug design, primarily due to their profound effect on pharmacological activity, which has led to the discovery of numerous broad-spectrum therapeutic agents. In the US FDA database, there are 95 approved pharmaceuticals that stem from pyridine or dihydro-pyridine, including isoniazid and ethionamide (tuberculosis), delavirdine (HIV/AIDS), abir-aterone acetate (prostate cancer), tacrine (Alzheimer's), ciclopirox (ringworm and athlete's foot), crizotinib (cancer), nifedipine (Raynaud's syndrome and premature birth), piroxicam (NSAID for arthritis), nilvadipine (hypertension), roflumilast (COPD), pyridostigmine (myasthenia gravis), and many more. Their remarkable therapeutic applications have encour-aged researchers to prepare a larger number of biologically active compounds decorated with pyridine or dihydropyridine, expandeing the scope of finding a cure for other ailments. It is thus anticipated that myriad new pharmaceuticals containing the two heterocycles will be available in the forthcoming decade. This review examines the prospects of highly potent bioactive molecules to emphasize the advantages of using pyridine and dihydropyridine in drug design. We cover the most recent developments from 2010 to date, highlighting the ever-expanding role of both scaffolds in the field of medicinal chemistry and drug development.

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