文献类型： 外文期刊
第一作者： Ding, Qianwen
作者： Ding, Qianwen;Hao, Qiang;Zhang, Qingshuang;Zhou, Zhigang;Ding, Qianwen;Olsen, Rolf Erik;Ringo, Einar;Yang, Yalin;Ran, Chao;Zhang, Zhen
作者机构：
关键词： high-fat diet; DHA; lipid accumulation; Cyclin D1; gut microbiota
期刊名称：FRONTIERS IN NUTRITION （ 影响因子：6.59； 五年影响因子：6.873 ）
ISSN： 2296-861X
年卷期： 2022 年 8 卷
页码：
收录情况： SCI
摘要： With the widespread use of high-fat diets (HFDs) in aquaculture, fatty livers are frequently observed in many fish species. The aim of this study was to investigate if docosahexaenoic acid (DHA) could be used to reduce the fatty liver in zebrafish generated by a 16% soybean oil-HFD over 2 weeks of feeding. The DHA was added to iso-lipidic HFD at 0.5, 1.0, and 2.0% of diet. Supplementation of DHA reduced growth and feed efficiency in a dose dependent manner being lowest in the HFDHA2.0 group. Hepatic triglyceride (TG) in zebrafish fed 0.5% DHA-supplemented HFD (HFDHA0.5) was significantly lower than in the HFD control. Transcriptional analyses of hepatic genes showed that lipid synthesis was reduced, while fatty acid beta-oxidation was increased in the HFDHA0.5 group. Furthermore, the expression of Cyclin D1 in liver of zebrafish fed HFDHA0.5 was significantly reduced compared to that in fish fed HFD. In zebrafish liver cells, Cyclin D1 knockdown and blocking of Cyclin D1-CDK4 signal led to inhibited lipid biosynthesis and elevated lipid beta-oxidation. Besides, DHA-supplemented diet resulted in a rich of Proteobacteria and Actinobacteriota in gut microbiota, which promoted lipid beta-oxidation but did not alter the expression of Cyclin D1 in germ-free zebrafish model. In conclusion, DHA not only inhibits hepatic lipid synthesis and promotes lipid beta-oxidation via Cyclin D1 inhibition, but also facilitates lipid beta-oxidation via gut microbiota. This study reveals the lipid-lowering effects of DHA and highlights the importance of fatty acid composition when formulating fish HFD.
分类号：
- 相关文献
作者其他论文 更多>>
-
Effect of crowding stress on liver health, gut permeability and gut microbiota of genetically improved farmed tilapia (GIFT, Oreochromis niloticus)
作者：Zhang, Jian;Chen, Jie;Liang, Hui;Li, Ming;Zhou, Wenhao;Zhou, Zhigang;Yang, Yalin;Zhang, Zhen;Ran, Chao;Ding, Qianwen
关键词：Crowing stress; Apoptosis; Gut permeability; Gut microbiota; GIFT
-
Based on Network Pharmacology and Molecular Docking, the Active Components, Targets, and Mechanisms of Flemingia philippinensis in Improving Inflammation Were Excavated
作者：Zhang, Dongying;Li, Xiaoyong;Zhou, Qixing;Zhang, Zhen;Yang, Xiangxuan;Wang, Dongxue;Man, Jiaxu
关键词：Flemingia philippinensis; improve inflammation; network pharmacology; molecular docking
-
Identification, comparative and phylogenetic analysis of eight Vitis species based on the chloroplast genome revealed their contribution to heat tolerance in grapevines
作者：Zhang, Lipeng;Liu, Jingjing;Liu, Huaifeng;Ma, Chao;Song, Yue;Li, Junpeng;Zhang, Zhen;Xu, Yuanyuan;Fan, Dongying;Liu, Mingying;Ren, Yi;He, Juan;Song, Shiren;Xu, Wenping;Ma, Chao;Xi, Xiaojun
关键词：Grape; Chloroplast genomes; Heat stress; Mutation hotspot; Phylogenetic analysis
-
A nuclease-dead Cas9-derived tool represses target gene expression
作者：Wang, Bowen;Liu, Xiaolin;Zeng, Kang;Guo, Jiangyi;Xin, Tongxu;Yang, Xueyong;Wang, Bowen;Li, Zhenxiang;Li, Jian-Feng;Zeng, Kang;Guo, Jiangyi;Zhang, Zhen
关键词：
-
Integrated Metagenomic and Metabolomic Analysis on Two Competing Mussels, Mytella strigata and Perna viridis, in China
作者：Zuo, Chenxia;Zuo, Chenxia;Ma, Xiaojie;Zhu, Yi;Yan, Shaojing;Zhang, Zhen;Ma, Peizhen;Ma, Peizhen;Ma, Xiaojie;Zhu, Yi;Zhang, Zhen
关键词：biological invasion; intestinal microbiota; metabolite; enzyme activity
-
Characterization and functional analysis of a novel C1q domain-containing protein from grass carp (Ctenopharyngodon idella) in response to bacterial challenge
作者：Zhang, Xia;Peng, Ran;Guo, Meixing;Li, Jianzhong;Zhang, Xia;Peng, Ran;Qu, Fufa;Guo, Meixing;Wu, Ting;He, Hao;Zhang, Yuhan;Jin, Kelan;Tang, Jianzhou;Liu, Zhen;Yang, Yalin;Zhou, Zhigang;Fan, Junde
关键词：Ctenopharyngodon idella; Ci C1ql2; Bacterial challenge; Complement; Intestinal immunity
-
Synthesis and Application of Specific N2H4 Fluorescent Probes with AIE Effect Based on Pyrazole Structure
作者：Yang, Yun-Shang;Zhang, Zhen;Zhang, Ying-Peng;Liang, Yu-Ning;Li, Xing-Xing;Yang, Yun-Shang;Zhang, Zhen;Zhang, Ying-Peng;Liang, Yu-Ning;Li, Xing-Xing;Teng, Zhi-Dong;Teng, Zhi-Dong
关键词：Pyrazole; N2H4 recognition; AIE effect; Cell imaging
