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Emergence of a Recombinant Bovine Enterovirus in China: Insights from Phylogenetic and Temporal Analysis

文献类型：外文期刊

第一作者： Feng, Guidan

作者： Feng, Guidan;Kang, Taisheng;Tang, Pan;Xie, Caihua;Yan, Ruoqian;Qian, Weidong

作者机构：

关键词： bovine enterovirus; diarrhea; molecular characterization; divergence dating; recombination breakpoints

期刊名称：ANIMALS （影响因子：2.7；五年影响因子：3.2 ）

ISSN： 2076-2615

年卷期： 2025 年 15 卷 10 期

页码：

收录情况： SCI

摘要： Bovine enteroviruses (BEVs) are emerging pathogens with poorly understood evolutionary dynamics and zoonotic potential. Here, we report the discovery of a novel recombinant BEV strain, HeN-2022, isolated from cattle in China. Genomic analysis revealed that HeN-2022 is a primary hybrid of BEV-E1 (VG527, Ireland) and BEV-E4 (GX1901, China), with recombination breakpoints in the VP1 gene and 5 ' UTR. Divergence dating traced its origin to 1991, predating closely related strains. Experimental infection in sheep demonstrated asymptomatic viral shedding (peak at 5 dpi) and robust neutralizing antibody responses, highlighting the potential cross-species adaptability. These findings underscore recombination as a potential key driver of BEV evolution and emphasize the need for global surveillance to address emerging livestock pathogens.

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