Autophagy mediated degradation of MITA/TBK1/IRF3 by a hnRNP family member attenuates interferon production in fish

文献类型： 外文期刊

第一作者： Zhang, Yanwei

作者： Zhang, Yanwei;Cen, Jing;Wu, Haixia;Gao, Wa;Zou, Jun;Zhang, Yanwei;Cen, Jing;Wu, Haixia;Gao, Wa;Zou, Jun;Zhang, Yanwei;Cen, Jing;Wu, Haixia;Gao, Wa;Zou, Jun;Jia, Zhiying;Adamek, Mikolaj;Zou, Jun

作者机构：

关键词： HnRNP A/B; Virus; Interferon; Autophagy

期刊名称：FISH & SHELLFISH IMMUNOLOGY （ 影响因子：4.7； 五年影响因子：4.7 ）

ISSN： 1050-4648

年卷期： 2024 年 149 卷

页码：

收录情况： SCI

摘要： HnRNP A/B belongs to the heterogeneous nuclear ribonucleoprotein (hnRNP) family and plays an important role in regulating viral protein translation and genome replication. Here, we found that overexpression of hnRNP A/B promoted spring viremia of carp virus (SVCV) and cyprinid herpesvirus 3 (CyHV3) replication. Further, hnRNP A/B was shown to act as a negative regulator of type I interferon (IFN) response. Mechanistically, hnRNP A/B interacted with MITA, TBK1 and IRF3 to initiate their degradation. In addition, hnRNP A/B bound to the kinase domain of TBK1, the C terminal domain of MITA and IAD domain of IRF3, and the RRM1 domain of hnRNP A/B bound to TBK1, RRM2 domain bound to IRF3 and MITA. Our study provides novel insights into the functions of hnRNP A/B in regulating host antiviral response.

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