Study on the stability of four flavonoid glycoside components in Myrica Rubra pomace and their mechanism of in vitro hypoglycaemic activity
文献类型: 外文期刊
第一作者: Tian, Siyi
作者: Tian, Siyi;Chang, Guoli;Xiang, Yannan;Cai, Chenggang;Luo, Xinyu;Zhu, Ruiyu;Yang, Hailong;Gao, Haiyan
作者机构: Zhejiang Univ Sci & Technol, Sch Biol & Chem Engn, Zhejiang Prov Key Lab Chem & Bio Proc Technol Farm, Hangzhou 310023, Peoples R China;Wenzhou Univ, Coll Life & Environm Sci, Wenzhou 325035, Peoples R China;Zhejiang Acad Agr Sci, Inst Food Sci, Hangzhou 310023, Peoples R China
关键词: Flavonoid glycoside; molecular docking; Myrica rubra pomace; alpha-glucosidase
期刊名称:INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY ( 2023影响因子:2.6; 五年影响因子:3.1 )
ISSN: 0950-5423
年卷期: 2024 年 59 卷 9 期
收录情况: SCI
摘要: In order to investigate the hypoglycaemic mechanism and potential applications of four hypoglycaemic flavonoid glycosides, namely myricitrin, Cyanidin-3-O-glucoside (C3G), hyperoside and quercitrin in Myrica rubra pomace, the stability of these four flavonoid glycosides and their binding mechanisms were studied using molecular docking. The results demonstrated that pH value affects on the stability of these four components in M. rubra pomace. C3G exhibited the most significant inhibitory effect on alpha-glucosidase at pH 5, with myricitrin, hyperoside and quercitrin showing the highest inhibitory effect at pH 7. Moreover, an increase in temperature and storage time reduced the inhibitory effect of these four glycosidic components on alpha-glucosidase. Molecular docking analysis revealed that myricitrin formed hydrogen bonds with the active site residues of alpha-glucosidase, namely Phe550, Ile552, Asp555, Ser574 and Arg576, and also engaged in hydrophobic interactions with Lys551. Hyperoside formed hydrogen bonds with alpha-glucosidase, formed hydrophobic interactions with Lys50 and exhibited pi-cation interaction with Lys53. Quercitrin formed hydrogen bonds with alpha-glucosidase, formed hydrophobic interactions with Lys500 and established salt bridges with Lys50. C3G formed hydrogen bonds and hydrophobic interactions with alpha-glucosidase and showed pi-pi interactions with Phe301. These findings will provide valuable insights for the application of these four chemicals.
- 相关文献
作者其他论文 更多>>
-
Novel pleuromutilin derivatives conjugated with phenyl-sulfide and boron-containing moieties as potent antibacterial agents against antibiotic-resistant bacteria
作者:Luo, Xinyu;Feng, Jing;Zhang, Jie;Yu, Hang;Han, Zunsheng;Zhu, Zihao;Liu, Bo;Wang, Yan;Zhang, Chi;Li, Tianlei;Zhang, Wenxuan;Wu, Song;Wu, Guangxu;Fu, Hengjian;Pan, Weidong;Nie, Wansen;Li, Beibei
关键词:Antimicrobial resistance; Pleuromutilin derivatives; Conjugated compounds; MRSA; Pleuromutilin-resistant strain
-
Prediction of moisture content of Agaricus bisporus slices as affected by vacuum freeze drying using hyperspectral imaging
作者:Bai, Shiqi;Xiao, Kunpeng;Liu, Qiang;Yang, Wenjian;Fang, Yong;Hu, Qiuhui;Pei, Fei;Xiao, Kunpeng;Mariga, Alfred Mugambi;Gao, Haiyan;Chen, Hangjun
关键词:Hyperspectral image; Agaricus bisporus; Support vector machine; Stability competitive adaptive reweighted sampling
-
The research on metabolomics mechanism of calcium ion-induced whole black bean polyphenols and biological activities
作者:Yang, Qingyu;Gu, Chenqi;Zhang, Xiling;Hu, Xiufa;Li, Man;Kong, Yanwen;Guan, Weichao;Gao, Haiyan
关键词:Black beans; Polyphenols; Metabolomics; Antioxidant activity; Hypoglycemic activity
-
Simulated gastrointestinal digestion of walnut protein yields anti-inflammatory peptides
作者:Xia, Wei;Fang, Xiangjun;Liu, Ruiling;Wu, Weijie;Gao, Haiyan;Yang, Hailong;Jin, Long;Deng, Yangyong;Gao, Junlong;Gao, Yuan;Wang, Li-Shu;Wang, Li-Shu
关键词:Walnut protein; Simulated digestion; Metabolic changes; Molecular docking; Inflammation; Cell experimental verification
-
VcMYB30 enhances wax production and maintains fruit quality by regulating cuticular wax biosynthesis genes
作者:Kong, Qi;Liu, Ruiling;Wu, Weijie;Chen, Huizhi;Han, Yanchao;Fang, Xiangjun;Zhang, Yiqin;Chen, Hangjun;Mu, Honglei;Gao, Haiyan;Chen, Jianye
关键词:Blueberries; Cuticular wax; Storage quality; Regulation; MYB
-
CA-g-CS/PLA film packaging improved storage stability through the MAPK signaling pathway of postharvest Agaricus bisporus
作者:Bai, Shiqi;Zhou, Zhicheng;Shang, Xueli;Ma, Ning;Yang, Wenjian;Hu, Qiuhui;Pei, Fei;Mariga, Alfred Mugambi;Fang, Donglu;Gao, Haiyan;Chen, Hangjun
关键词:Agaricus bisporus; Chitosan-caffeic acid/polylactic acid film; packaging; MAPK signaling pathway; Storage stability
-
Differential Analysis of Pomelo Peel Fermentation by Cordyceps militaris Based on Untargeted Metabolomics
作者:Xiang, Yannan;Tian, Siyi;Luo, Xinyu;Cai, Chenggang;Du, Yaowen;Yang, Hailong;Gao, Haiyan
关键词:pomelo peel; Cordyceps militaris; fermentation; multivariate statistical analysis; untargeted metabolomics