Inhibition of eIF2 alpha Phosphorylation by Peste des Petits Ruminant Virus Phosphoprotein Facilitates Viral Replication

文献类型： 外文期刊

第一作者： Alfred, Niyokwishimira

作者： Alfred, Niyokwishimira;Qian, Bang;Qin, Xiaodong;Yin, Xiangping;Prajapati, Meera;Dou, Yongxi;Alfred, Niyokwishimira;Prajapati, Meera;Li, Yanmin;Zhang, Zhidong

作者机构：

关键词： peste des petits ruminants virus; dephosphorylation; eIF2 alpha; GADD34; phosphoprotein

期刊名称：FRONTIERS IN VETERINARY SCIENCE （ 影响因子：3.412； 五年影响因子：3.588 ）

ISSN：

年卷期： 2021 年 8 卷

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收录情况： SCI

摘要： Peste des petits ruminant virus (PPRV) causes a highly contagious disease in small ruminants. The molecular mechanism of PPRV replication and its interactions with hosts are poorly studied. In other paramyxoviruses, the viral phosphoprotein (P) has been associated with multiple functions for key biological processes such as the regulation of transcription, translation, and the control of cell cycle. Phosphorylation of the alpha subunit of eukaryotic initiation factor 2 (eIF2 alpha) is an important process for gene regulation in host cells under stress, including viral infection. In the present study, molecular mechanisms associated with PPRV replication and viral interaction with host cells were investigated. We describe the ability of PPRV to dephosphorylate eIF2 alpha and the potential of PPRV P protein to induce the host cellular growth arrest DNA damage protein (GADD34), which is known to be associated with eIF2 alpha dephosphorylation. Furthermore, we observed that PPRV P protein alone could block PERK/eIF2 alpha phosphorylation. We speculate that PPRV exploits eIF2 alpha dephosphorylation to facilitate viral replication and that PPRV P protein is involved in this molecular mechanism. This work provides new insights into further understanding PPRV pathobiology and its viral/host interactions.

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