(3-Cyclodextrin/cationic-cellulose/naringenin complex-stabilized Pickering lemon emulsions with enhanced bioavailability

文献类型： 外文期刊

第一作者： Liu, Ting

作者： Liu, Ting;Chen, Yuying;Wang, Yanqi;Wang, Xueping;Zheng, Jinkai;Wang, Yanqi;Wang, Xueping;Zheng, Jinkai

作者机构：

关键词： Pickering emulsion; Encapsulation; Release; Bioaccessibility; Bioavailability

期刊名称：FOOD HYDROCOLLOIDS （ 影响因子：12.4； 五年影响因子：13.3 ）

ISSN： 0268-005X

年卷期： 2025 年 166 卷

页码：

收录情况： SCI

摘要： A low loading capacity and gastrointestinal instability are critical issues that need to be addressed to improve the bioavailability of conventional Pickering emulsions (CPEs). Using naringenin, a citrus-derived bioactive compound with multiple health-promoting effects as an example, this study developed a novel (3-cyclodextrin/ cationic cellulose/naringenin complex ((3-CD/C-CNC/Nar) as an emulsifier to construct a novel Pickering emulsion (NPE), in which naringenin is present in the complex at the oil-water interface; this is distinct from a CPE that loads naringenin in the oil phase. The loading capacity (0.9 mg/mL) of the NPE was increased at least 10 times compared to the CPE. The 24-h apparent stability, centrifugal stability, and thermal stability of the NPE was improved after dissolving LMP, a natural polysaccharide that enhances emulsion stability by increasing the viscosity, which could form a three-dimensional network through hydrogen bonding interactions at a lower pH. In vitro simulated digestion showed that the NPE with 2 wt% LMP effectively resisted digestive environment stress, especially in the gastric phase, and significantly improved the bioaccessibility (41.01%) and naringenin release percentage (44.0%). In vivo pharmacokinetic tests demonstrated that the NPE with 2 wt% LMP had excellent bioavailability (Cmax 0.27 mu g/mL, AUC0 -> 24 9.56 h mu g/mL) and sustained-release effect (Tmax 2 h). This study provides new insights into the development of flavor NPEs for the efficient in vivo delivery of hydrophobic bioactive compounds.

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