Preparation and Regulation of Natural Amphiphilic Zein Nanoparticles by Microfluidic Technology

文献类型： 外文期刊

第一作者： Liu, Zhe

作者： Liu, Zhe;Ma, Xiaojie;Hei, Xue;Zhang, Xinyu;Hu, Hui;Zhu, Jinjin;Wang, Qiang;Shi, Aimin;Ge, Yanzheng;Adhari, Benu;Wang, Qiang;Wang, Qiang;Shi, Aimin

作者机构：

关键词： zein nanoparticles; microfluidic technology; solvent polarity; emulsifying property

期刊名称：FOODS （ 影响因子：4.7； 五年影响因子：5.1 ）

ISSN：

年卷期： 2024 年 13 卷 11 期

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收录情况： SCI

摘要： Microfluidic technology, as a continuous and mass preparation method of nanoparticles, has attracted much attention in recent years. In this study, zein nanoparticles (ZNPs) were continuously fabricated in a highly controlled manner by combining a microfluidics platform with the antisolvent method. The impact of ethanol content (60 similar to 95%, v/v) and flow rates of inner and outer phases in the microfluidics platform on particle properties were examined. Among all ZNPS, 90%-ZNPs have the highest solubility (32.83%) and the lowest hydrophobicity (90.43), which is the reverse point of the hydrophobicity of ZNPs. Moreover, when the inner phase flow rate was 1.5 mL/h, the particle size decreased significantly from 182.81 nm to 133.13 nm as the outer phase flow rate increased from 10 mL/h to 50 mL/h. The results revealed that ethanol content had significant impacts on hydrophilic-hydrophobic properties of ZNPs. The flow rates of ethanol-water solutions and deionized water (solvent and antisolvent) in the microfluidics platform significantly affected the particle size of ZNPs. These findings demonstrated that the combined application of a microfluidics platform and an antisolvent method could be an effective pathway for precisely controlling the fabrication process of protein nanoparticles and modulating their physicochemical properties.

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