文献类型： 外文期刊
第一作者： Wang, Yijing
作者： Wang, Yijing;Peng, Dingkun;Li, Meilin;Yao, Meng;Li, Tianlong;Li, Su;Qiu, Hua-Ji;Li, Lian-Feng;Yao, Meng;Li, Tianlong;Li, Lian-Feng
作者机构：
关键词： organoids; viral infections; disease models; stem cells; host-virus interactions
期刊名称：JOURNAL OF VIROLOGY （ 影响因子：3.8； 五年影响因子：3.9 ）
ISSN： 0022-538X
年卷期： 2025 年
页码：
收录情况： SCI
摘要： Viral diseases pose serious threats to human health, resulting in substantial economic losses. However, traditional disease models often fail to capture the full complexity of viral pathogenesis. Pluripotent and tissue stem cell-derived organoids help bridge this gap by closely mimicking the structure and function of native organs, thereby enabling new breakthroughs in studying viral pathogenesis. This review discusses the diverse applications of organoid models in virology, including infection modeling, host-virus interaction studies, CRISPR/Cas9-based gene editing, antiviral drug screening, and vaccine development. Here, we focus on human organoid models used to investigate viral infections, covering systemic viral infections (exemplified by viruses such as SARS-CoV-2, Zika virus, influenza virus, and monkeypox virus) as well as localized viral infections (exemplified by viruses including respiratory syncytial virus, herpes simplex virus 1, rotavirus, norovirus, hepatobiliary viruses, and cytomegalovirus). By advancing mechanistic insights and accelerating therapeutic discovery, organoid technology shows significant potential as a complementary tool for combating viral diseases.
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