Suppression of diabetes in non-obese diabetic (NOD) mice by oral administration of water-soluble and alkali-soluble polysaccharide conjugates prepared from green tea

文献类型: 外文期刊

第一作者: Chen, Xiaoqiang

作者: Chen, Xiaoqiang;Lin, Zhi;Ye, Yang;Yin, Junfeng;Jiang, Yongwen;Zhang, Rui;Wan, Haitong

作者机构:

关键词: Tea polysaccharide conjugates;Non-obese diabetic (NOD) mice;Suppression;Green tea;Insulin-dependent diabetes mellitus;(IDDM)

期刊名称:CARBOHYDRATE POLYMERS ( 影响因子:9.381; 五年影响因子:8.678 )

ISSN:

年卷期:

页码:

收录情况: SCI

摘要: Water-soluble tea polysaccharide conjugates (TPC-W) and alkali-soluble tea polysaccharide conjugates (TPC-A) were extracted from green tea by hot and alkali water respectively. Physicochemical properties of TPC-W and TPC-A were analyzed. Non-obese diabetic (NOD) mice were used to evaluate antidiabetic bioactivities of TPC-W and TPC-A. The daily oral administration of 150 mg kg~(-1) TPC-W can significantly decrease the level of blood glucose in NOD mice. The anti-glutamic acid decarboxylase (GAD) antibody level in NOD mice treated with 150mgkg~(-1) TPC-W decreased 27% (P<0.05). To the end of trial, only 2 out of 10 mice in NOD groups treated with TPC-W or TPC-A exhibited diabetic symptoms compared with model control group, in which 7 of 10 mice developed diabetes. The result of organ index showed that both TPC-W and TPC-A can protect thymus from shriveling to some extent. In sum, our studies demonstrated that both TPC-W and TPC-A can suppress spontaneous diabetes mellitus in NOD mice.

分类号: O629

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