Swine NONO is an essential factor to inhibit pseudorabies virus infection

文献类型： 外文期刊

第一作者： Jiang, Dandan

作者： Jiang, Dandan;Jiang, Chenlong;Jiang, Dandan;Sui, Chao;Wu, Xiangju;Hu, Yue;Cong, Xiaoyan;Li, Juntong;Du, Yijun;Qi, Jing;Lee, Changhee;Lee, Changhee

作者机构：

关键词： Pseudorabies virus; IFN-?; ISGs; SNONO

期刊名称：VETERINARY MICROBIOLOGY （ 影响因子：3.246； 五年影响因子：3.565 ）

ISSN： 0378-1135

年卷期： 2022 年 275 卷

页码：

收录情况： SCI

摘要： Pseudorabies virus (PRV) is a member of the genus Varicellovirus, family Herpesviridae and causes Aujeszky's disease to lead to huge economic losses in the global pig industry. The Non-POU domain-containing octamer-binding protein (NONO), as a Drosophila behavior/human splicing (DBHS) protein, plays a key role in multi-ple biological functions in cells, including transcriptional regulation, RNA splicing, DNA repair and so on. However, whether swine NONO (sNONO) inhibits PRV infection is less understood. In this study, we showed that sNONO was a crucial host factor for antagonizing PRV infection and positive regulated transcription levels of ISGs. After PRV infection, sNONO enhanced the activation of IFN-beta promoter and IFN-beta expression. Furthermore, knockout of sNONO in PAM-KNU cells impaired activation of type I IFN pathway and increased PRV propagation. Taken together, we have first elucidated the anti-PRV function and mechanism of sNONO, which may provide a new strategy for preventing DNA virus infection.

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