The HPV viral regulatory mechanism of TLRs and the related treatments for HPV-associated cancers

文献类型： 外文期刊

第一作者： Qi, Shi-Yu

作者： Qi, Shi-Yu;Yu, Kun;Yang, Miao-Miao;Li, Chong-Yang;Deng, Shou-Long

作者机构：

关键词： human papillomavirus; toll-like receptors; TLR agonists; cancer; TLR therapy

期刊名称：FRONTIERS IN IMMUNOLOGY （ 影响因子：7.3； 五年影响因子：8.0 ）

ISSN： 1664-3224

年卷期： 2024 年 15 卷

页码：

收录情况： SCI

摘要： Infection with human papillomavirus (HPV) typically leads to cervical cancer, skin related cancers and many other tumors. HPV is mainly responsible for evading immune tumor monitoring in HPV related cancers. Toll like receptors (TLRs) are particular pattern recognition molecules. When the body is facing immune danger, it can lead to innate and direct adaptive immunity. TLR plays an important role in initiating antiviral immune responses. HPV can affect the expression level of TLR and interfere with TLR related signaling pathways, resulting in sustained viral infection and even carcinogenesis. This paper introduces the HPV virus and HPV related cancers. We discussed the present comprehension of TLR, its expression and signaling, as well as its role in HPV infection. We also provided a detailed introduction to immunotherapy methods for HPV related diseases based on TLR agonists. This will provide insights into methods that support the therapeutic method of HPV related conditions with TLR agonists The figure shows the infection factors of HPV, HPV related cancers, and related treatment plans. There are multiple behaviors and factors that can cause HPV infection, including early initiation of sexual activity, multiple sexual partners, childbearing age is young or has multiple pregnancies, long term smoking, long term oral contraceptive pills and weak immunity. Long-term HPV infection can lead to the formation of various cancers, including head and neck cancer, cervical cancer, vaginal cancer, anal cancer and skin cancer. There are currently multiple methods available for preventing and treating related cancers, including therapeutic vaccines, T-cell therapy, natural compounds, nucleic acids based therapy, TLR agonists, checkpoint inhibitor monoclonal antibody.

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