Paeonol promotes longevity and fitness in Caenorhabditis elegans through activating the DAF-16/FOXO and SKN-1/Nrf2 transcription factors

文献类型： 外文期刊

第一作者： Li, Rong

作者： Li, Rong;Yi, Qingping;Wang, Jinsong;Miao, Yuanxin;Chen, Qingchan;Xu, Yan;Tao, Mingfang

作者机构：

关键词： Caenorhabditis elegans; Anti-aging; Paeonol; Stress resistance; IIS pathway

期刊名称：BIOMEDICINE & PHARMACOTHERAPY （ 影响因子：7.5； 五年影响因子：6.8 ）

ISSN： 0753-3322

年卷期： 2024 年 173 卷

页码：

收录情况： SCI

摘要： Paeonol, as one of the most abundant plant -derived polyphenols, has multiple bioactivities including antiinflammatory, anti -tumor, and anti -cardiovascular diseases. Nevertheless, the anti -aging effects and related mechanisms of paeonol are rarely reported. In this study, we found that paeonol significantly prolonged the mean lifespan of Caenorhabditis elegans (C. elegans) by 28.49% at a dose of 200 mu M. Moreover, paeonol promoted the health of C. elegans by increasing the body bending and pharyngeal pumping rates and reducing the lipofuscin accumulation level. Meanwhile, paeonol induced the expression of stress -related genes or proteins by activating the transcription factors DAF-16/FOXO, SKN-1/Nrf2, and HSF-1, which in turn enhanced oxidative and thermal stress tolerance. The mechanism behind the anti -aging effect of paeonol occurred by downregulating the insulin/IGF-1 signaling (IIS) pathway. Our findings shed new light on the application of paeonol for longevity promotion and human health.

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