Comparative analysis of the genetic diversity of the neutral microsatellite loci and second exon of the goat MHC-DQB1 gene

文献类型： 外文期刊

第一作者： Gong, Ying

作者： Gong, Ying;Guo, Yi;He, Yong-Meng;Yuan, Ying;Yang, Bai-Gao;Duan, Xing-Hai;Liu, Cheng-Li;Zhang, Jia-Hua;Na, Ri-Su;Han, Yan-Guo;Zeng, Yan;Huang, Yong-Fu;Zhao, Yong-Ju;Zhao, Zhong-Quan;Guangxin, E.;Hong, Qiong-Hua;Ma, Yue-Hui

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关键词： Major histocompatibility complex (MHC); microsatellite markers; goats; genetic diversity; selection

期刊名称：ANIMAL BIOTECHNOLOGY （ 影响因子：2.271； 五年影响因子：1.697 ）

ISSN： 1049-5398

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收录情况： SCI

摘要： This study compared and analyzed the genetic diversity and population structure of exon 2 of the DQB1 gene and 13 autosomal neutral microsatellite markers from 14 Chinese goat breeds to explore the potential evolutionary mechanism of the major histocompatibility complex (MHC). A total of 287 haplotypes were constructed from MHC-DQB1 exon 2 from 14 populations, and 82 nucleotide polymorphic sites (SNPs, 31.78%) and 172 heterozygous individuals (79.12%) were identified. The F-ST values of the microsatellites and MHC-DQB ranged between 0.01831-0.26907 and 0.00892-0.38871, respectively. Furthermore, 14 goat populations showed rich genetic diversity in the microsatellite loci and MHC-DQB1 exon 2. However, the population structure and phylogenetic relationship represented by the two markers were different. Positive selection and Tajima's D test results showed the occurrence of a diversified selection mechanism, which was primarily based on a positive and balancing selection in goat DQB. This study also found that the DQB sequences of bovines exhibited trans-species polymorphism (TSP) among species and families. In brief, this study indicated that positive and balancing selection played a major role in maintaining the genetic diversity of DQB, and TSP of MHC in bovines was common, which enhanced the understanding of the MHC evolution.

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