Dysregulated Signaling Pathways in Canine Mammary Tumor and Human Triple Negative Breast Cancer: Advances and Potential Therapeutic Targets
文献类型： 外文期刊
第一作者： Mei, Chen
作者： Mei, Chen;Liu, Ying;Liu, Zhenyi;Zhi, Yan;Jiang, Zhaoling;Wang, Hongjun;Lyu, Xueze
作者机构：
关键词： human breast cancer; canine mammary tumor; signaling pathways; drug targets
期刊名称：INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES （ 影响因子：4.9； 五年影响因子：5.7 ）
ISSN： 1661-6596
年卷期： 2025 年 26 卷 1 期
页码：
收录情况： SCI
摘要： In 2022, human breast cancer (HBC) and canine mammary tumors (CMTs) remained the most prevalent malignant tumors worldwide, with high recurrence and lethality rates, posing a significant threat to human and dog health. The development of breast cancer involves multiple signaling pathways, highlighting the need for effective inhibitory drugs that target key proteins in these pathways. This article reviews the dysregulation of the EGFR, PI3K/AKT/mTOR, Hippo, pyroptosis, and PD-1/PD-L1 signaling pathways in HBC and CMT, as well as the corresponding drugs used to inhibit tumor growth, with the aim of providing theoretical support for the development of more efficient drugs.
分类号：
- 相关文献
作者其他论文 更多>>
-
Glutathione reductase modulates endogenous oxidative stress and affects growth and virulence in Avibacterium paragallinarum
作者：Zhi, Yan;Mei, Chen;Liu, Zhenyi;Liu, Ying;Wang, Hongjun
关键词：Glutathione reductase;
Av. paragallinarum ; Oxidative stress; Bacterial virulence; Redox homeostasis; Metabolic adaptation -
CsCBF1/CsZHD9-CsMADS27, a critical gene module controlling dormancy and bud break in tea plants
作者：Hao, Xinyuan;Tang, Junwei;Chen, Yao;Huang, Chao;Zhang, Weifu;Liu, Ying;Wang, Lu;Ding, Changqing;Yang, Yajun;Wang, Xinchao;Chen, Yao;Yue, Chuan;Liu, Ying;Dai, Wenhao;Horvath, David P.
关键词：bud dormancy; bud break; MADS-box; gene function; regulatory network;
Camellia sinensis -
A Rapid PCR-LAMP Assay for the Early Detection of Lasiodiplodia theobromae from Basal Stem Rot-Infected Passion Fruit Plants
作者：Liu, Ying;Rasheed, Usman;Shan, Bin;Lu, Qinyu;Chen, Shimiao;Meng, Kaikai;Mo, Ganhui;Liu, Ying;Rasheed, Usman;Shan, Bin;Lu, Qinyu;Chen, Shimiao;Meng, Kaikai;Mo, Ganhui;Qin, Aiying
关键词：Passion fruit; Basal stem rot; Loop-mediated isothermal amplification; Hydroxy naphthol blue; Phytopathogen detection;
Lasiodiplodia theobromae -
Mechanisms underlying the effects of cyanogenesis on development and reproduction of Tetranychus urticae: Insights from enzyme activity and gene expression aspects
作者：Wu, Mufeng;Zhao, Zihua;Li, Zhihong;Wu, Mufeng;Liang, Xiao;Liu, Ying;Wu, Chunling;An, Xingkui;Hao, Guifeng;Gregory, Ijiti Oluwole;Chen, Qing;Wu, Mufeng;Zhao, Zihua;Li, Zhihong;Wu, Mufeng;Liang, Xiao;Liu, Ying;Wu, Chunling;An, Xingkui;Hao, Guifeng;Gregory, Ijiti Oluwole;Chen, Qing
关键词：Cyanogenesis; Tetranychus urticae; Development and reproduction; Enzyme activity; Gene expression
-
Synergistic antimicrobial efficacy of glabrol and colistin through micelle-based co-delivery against multidrug-resistant bacterial pathogens
作者：Liu, Ying;Zhang, Mengying;Qu, Shaoqi;Liu, Ying;Mei, Chen;Wang, Hongjun;Cai, Yawei;Wu, Shuaicheng
关键词：Gram-negative bacteria; Colistin; Glabrol; Synergistic antibacterial; Micelle
-
Interactions, properties and lipid digestibility of attractive Pickering emulgels formed by sequential addition of oppositely charged nanopolysaccharides
作者：Guo, Shasha;Ji, Xingxiang;Guo, Shasha;Li, Jun;Huang, Luyao;Guo, Shasha;Wan, Zhangmin;Niu, Xun;Xu, Junhua;Liu, Ying;Bai, Long;Lu, Yi;Rojas, Orlando J.;Jiao, Wenjuan;Zheng, Jianan;Li, Bin;Bai, Long;Lu, Yi;Rojas, Orlando J.;Rojas, Orlando J.
关键词：
-
Contamination of aflatoxin B1, deoxynivalenol and zearalenone in feeds in China from 2021 to 2024
作者：Liu, Meng;Xia, Zhiyuan;Sun, Hua;He, Jiangfeng;Sun, Lvhui;Liu, Meng;Xia, Zhiyuan;Zhang, Yu;Lamesgen, Dessalegn;Sun, Lvhui;Yang, Rengui;Luo, Weicai;Guo, Lijia;Liu, Ying
关键词：Aflatoxin B-1; China; Contamination; Deoxynivalenol; Feeds; Zearalenone
