A multi-tissue atlas of regulatory variants in cattle

文献类型： 外文期刊

第一作者： Liu, Shuli

作者： Liu, Shuli;Gao, Yahui;Li, Congjun;Rosen, Benjamin D.;Van Tassell, Curtis P.;Vanraden, Paul M.;Cole, John B.;Liu, George E.;Fang, Lingzhao;Liu, Shuli;Yu, Ying;Yan, Ze;Zhang, Shengli;Liu, Shuli;Gao, Yahui;Ma, Li;Canela-Xandri, Oriol;Pairo-Castineira, Erola;D'Mellow, Kenton;Yao, Yuelin;Navarro, Pau;Tenesa, Albert;Fang, Lingzhao;Wang, Sheng;Cai, Wentao;Li, Bingjie;Xiang, Ruidong;Xiang, Ruidong;Chamberlain, Amanda J.;Pairo-Castineira, Erola;Rawlik, Konrad;Xia, Charley;Tenesa, Albert;Rocha, Dominique;Li, Xiujin;Fang, Lingzhao

作者机构：

期刊名称：NATURE GENETICS （ 影响因子：41.307； 五年影响因子：39.321 ）

ISSN： 1061-4036

年卷期： 2022 年 54 卷 9 期

页码：

收录情况： SCI

摘要： Characterization of genetic regulatory variants acting on livestock gene expression is essential for interpreting the molecular mechanisms underlying traits of economic value and for increasing the rate of genetic gain through artificial selection. Here we build a Cattle Genotype-Tissue Expression atlas (CattleGTEx) as part of the pilot phase of the Farm animal GTEx (FarmGTEx) project for the research community based on 7,180 publicly available RNA-sequencing (RNA-seq) samples. We describe the transcriptomic landscape of more than 100 tissues/cell types and report hundreds of thousands of genetic associations with gene expression and alternative splicing for 23 distinct tissues. We evaluate the tissue-sharing patterns of these genetic regulatory effects, and functionally annotate them using multiomics data. Finally, we link gene expression in different tissues to 43 economically important traits using both transcriptome-wide association and colocalization analyses to decipher the molecular regulatory mechanisms underpinning such agronomic traits in cattle. The cattle Genotype-Tissue Expression atlas of expression and splicing QTLs is generated from 7,180 uniformly re-processed RNA-seq samples. Integration with GWAS identifies candidate genes and variants associated with economically important traits.

分类号：

  • 相关文献
作者其他论文 更多>>

微信小程序