Hydroxylated hierarchical flower-like COF for solid-phase extraction of adrenergic receptor agonists in milk

文献类型： 外文期刊

第一作者： Xu, Guiju

作者： Xu, Guiju;Yang, Chunlei;Zhang, Hongwei;Hou, Chenghao;Peng, Lizeng;Liu, Chuqing;Zhao, Ru-Song;Wang, Lei

作者机构：

关键词： Adrenergic receptor agonists; Hydroxylated COF; SPE; LC-MS/MS; Milk analysis

期刊名称：MICROCHIMICA ACTA （ 影响因子：5.7； 五年影响因子：5.4 ）

ISSN： 0026-3672

年卷期： 2024 年 191 卷 6 期

页码：

收录情况： SCI

摘要： A new detection platform based on a hydroxylated covalent organic framework (COF) integrated with liquid chromatography-tandem mass spectrometry (LC-MS/MS) was constructed and used for detecting adrenergic receptor agonists (ARAs) residues in milk. The hydroxylated COF was prepared by polymerization of tris(4-aminophenyl)amine and 1,3,5-tris(4-formyl-3-hydroxyphenyl)benzene and applied to solid-phase extraction (SPE) of ARAs. This hydroxylated COF was featured with hierarchical flower-like morphology, easy preparation, and copious active adsorption sites. The adsorption model fittings and molecular simulation were applied to explore the potential adsorption mechanism. This detection platform was suitable for detecting four alpha 2- and five beta 2-ARAs residues in milk. The linear ranges of the ARAs were from 0.25 to 50 mu gkg-1; the intra-day and the inter-day repeatability were in the range 2.9-7.9% and 2.0-10.1%, respectively. This work demonstrates this hydroxylated COF has great potential as SPE cartridge packing, and provides a new way to determine ARAs residues in milk.

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