Development of a quinoline-derived turn-on fluorescent probe for real time detection of hydrazine and its applications in environment and bioimaging

文献类型： 外文期刊

第一作者： Muthusamy, Selvaraj

作者： Muthusamy, Selvaraj;Rajalakshmi, Kanagaraj;Meng, Suci;Xie, Meng;Xie, Jimin;Xu, Yuanguo;Yin, Siqi;Zhu, Dongwei;Yin, Siqi;Zhu, Dongwei;Lodi, Rathna Silviya

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关键词： Quinoline-2; 4-dinitrobenzoate; Hydrazine -toxic; ICT-AIE; Smartphone; Real sample; In situ hydrazine

期刊名称：DYES AND PIGMENTS （ 影响因子：5.122； 五年影响因子：4.36 ）

ISSN： 0143-7208

年卷期： 2022 年 206 卷

页码：

收录情况： SCI

摘要： Hydrazine is a highly toxic pollutant to the environment and living organisms. Therefore, it is an urgent need to detect hydrazine selectively, sensitively, and successfully in the real samples and biosystems. Thus, we designed a donor-pi-acceptor fluorophore quinoline (Q) appended 4-formylphenyl 2,4-dinitrobenzoate (P-DNP) to form a Schiff base QP-DNP for tracking hydrazine in real samples and biosystems. The probe observes an intramolecular charge transfer and aggregation induced emission sensing mechanisms on cleavage of ester bond upon nucleo-philic substitution reaction with hydrazine and exhibited a "turn-on " fluorescence at green channel with the formation of quinoline-phenol. The proposed study was investigated through photophysical properties, 1H NMR titration, HR-MS experiments, and density-functional theory calculations. The LOD of QP-DNP for hydrazine was calculated to be 55 nM and exhibited a high selectivity among possible competitive analytes. Additionally, the probe showed a remarkable emission colour changes on fabrication of paper sensor strips that can be discrim-inated in monitoring hydrazine vapor using smartphone and achieved an AND gate operation. Furthermore, QP-DNP was successfully applied to fluorescence imaging of hydrazine in live HeLa cells, monitoring of in situ hydrazine release as a metabolite of isoniazid drug administrated orally and determining hydrazine contami-nation in real samples.

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