TRIM21 interacts with IκBα and negatively regulates NF-κB activation in Corynebacterium pseudotuberculosis-infected macrophages

文献类型： 外文期刊

第一作者： Wu, Chanyu

作者： Wu, Chanyu;Wang, Xiaohan;Li, Xincan;Peng, Qiuyue;Niu, Xiaoxin;Wang, Zhiying;Zhou, Zuoyong;Li, Hexian;Wu, Yutong

作者机构：

关键词： Corynebacterium pseudotuberculosis; TRIM21; Macrophages; NF-kappa B

期刊名称：VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY （ 影响因子：1.4； 五年影响因子：1.6 ）

ISSN： 0165-2427

年卷期： 2025 年 282 卷

页码：

收录情况： SCI

摘要： Corynebacterium pseudotuberculosis, a zoonotic intracellular bacteria, is responsible for abscesses and pyogranuloma formation of the infected host, which is essentially a chronic inflammatory response. Tripartite motif- containing protein 21 (TRIM21) negatively regulates pro-inflammatory cytokines production during C. pseudo- tuberculosis infection, the mechanism of which remains unclear. This study found that C. pseudotuberculosis infection in macrophages induced phosphorylation of I kappa B and p65. TRIM21 interacted with I kappa B alpha by PRY/SPRY domain, stabilizes I kappa B alpha and negatively regulates I kappa B alpha phosphorylation in macrophages during C. pseudotuberculosis infection. In addition, TRIM21 positively regulates the ubiquitination of I kappa B alpha via K48 linkage rather than K63 linkage in C. pseudotuberculosis-infected macrophages. In brief, our research confirmed that TRIM21 negatively regulates canonical NF-kappa B activation by interacting with I kappa B alpha and decreasing I kappa B alpha phosphorylation in macrophages during C. pseudotuberculosis infection. Preventing inflammation induced by C. pseudotuberculosis infection through regulation of the NF-kappa B pathway is a potential way to control this pathogen.

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