TET2 is required for Type I IFN-mediated inhibition of bat-origin swine acute diarrhea syndrome coronavirus

文献类型： 外文期刊

第一作者： Duan, Yueyue

作者： Duan, Yueyue;Yuan, Cong;Suo, Xuepeng;Cao, Liyan;Kong, Xiangyu;Li, Xiangtong;Wang, Qi;Duan, Yueyue;Yuan, Cong;Suo, Xuepeng;Cao, Liyan;Kong, Xiangyu;Li, Xiangtong;Zheng, Haixue;Wang, Qi;Duan, Yueyue;Yuan, Cong;Suo, Xuepeng;Cao, Liyan;Kong, Xiangyu;Li, Xiangtong;Wang, Qi

作者机构：

关键词： coronavirus; local infection; replication; spread pathogenesis; zoonoses

期刊名称：JOURNAL OF MEDICAL VIROLOGY （ 影响因子：20.693； 五年影响因子：12.203 ）

ISSN： 0146-6615

年卷期： 2022 年 94 卷 7 期

页码：

收录情况： SCI

摘要： Swine acute diarrhea syndrome coronavirus (SADS-CoV) is a newly discovered bat-origin coronavirus with fatal pathogenicity for neonatal piglets. There is no vaccine to prevent SADS-CoV infection or clinically approved drugs targeting SADS-CoV. Therefore, unraveling cellular factors that regulate SADS-CoV for cell entry is critical to understanding the viral transmission mechanism and provides a potential therapeutic target for SADS-CoV cure. Here, we showed that Type I interferon (IFN-I) pretreatment potently blocks SADS-CoV entry into cells using lentiviral pseudo-virions as targets whose entry is driven by the SADS-CoV Spike glycoprotein. IFN-I-mediated inhibition of SADS-CoV entry and replication was dramatically impaired in the absence of TET2. These results suggest TET2 is found to serve as a checkpoint of IFN-I-meditated inhibition on the cell entry of SADS-CoV, and our discovery might constitute a novel treatment option to combat against SADS-CoV.

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