LC-MS Guided Discovery and Biosynthetic Pathway of Coprisamides E-H, Cinnamic Acid-Containing Metabolites from the Marine Algae-Derived Streptomyces thermolineatus NAK03196
文献类型： 外文期刊
第一作者： Zhang, Guo Dong
作者： Zhang, Guo Dong;Yang, Zhi Wei;Yin, Fang Zhou;Yan, Zhang Yuan;Guo, Zhi Kai;Jiao, Rui Hua;Xiong, Zi Jun;Ma, Shuai;Guo, Zhi Kai;Xiong, Zi Jun;Ma, Shuai;Guo, Zhi Kai
作者机构：
期刊名称：JOURNAL OF NATURAL PRODUCTS （ 影响因子：3.6； 五年影响因子：4.2 ）
ISSN： 0163-3864
年卷期： 2025 年 88 卷 3 期
页码：
收录情况： SCI
摘要： Four cinnamoyl-containing nonribosomal peptides (CCNPs), coprisamides E-H (1-4), were isolated from the marine algae-associated actinomycete strain Streptomyces thermolineatus NAK03196. Their structures were elucidated to be unreported coprisamides by comprehensive analyses of HRESIMS, 1D and 2D NMR spectroscopic data, Marfey's method, and MS/MS analysis. Coprisamides E (1) and F (2) bear a characteristic nonproteinogenic amino acid, 2,3-diaminopropanoic acid. The biosynthetic pathways for these isolates were proposed through a comparison of their biosynthetic gene clusters with reported homologous gene clusters. Coprisamide E (1) exhibited weak antibacterial activity against the Gram-positive strain Staphylococcus aureus.
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