Comparative Insecticidal Activity and Mechanism of Isocycloseram versus Other GABAergic Insecticides against the Fall Armyworm

文献类型： 外文期刊

第一作者： Liu, Xinyu

作者： Liu, Xinyu;Liu, Feifan;Wang, Junyan;Wang, Ying;Huang, Qiutang;Wang, Qiuxia;Zhao, Chunqing;Tang, Tao

作者机构： Nanjing Agr Univ, Coll Plant Protect, Minist Agr, Key Lab Integrated Pest Management Crops East Chin, Nanjing 210095, Peoples R China;Hunan Acad Agr Sci, Inst Plant Protect, Changsha 410125, Peoples R China

关键词： isoxazolines; chloride channel; RDL subunit; cys-loop receptor

期刊名称：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY （ 2023影响因子：5.7； 五年影响因子：6.0 ）

ISSN： 0021-8561

年卷期： 2024 年 72 卷 34 期

页码：

收录情况： SCI

摘要： The fall armyworm (FAW) is a serious agricultural pest and has developed resistance to multiple insecticides. It is necessary to introduce novel insecticide(s) for controlling FAW. Isocycloseram is a completely novel isoxazoline insecticide. However, its activity and mode of action against FAW have not been reported. In this study, isocycloseram exhibited a higher insecticidal activity (LC50 = 0.26 mg/kg) than fipronil (LC50 = 7.72 mg/kg) against FAW. The median inhibitory concentration (IC50) of isocycloseram (IC50 = 8.52 nM) was almost equal to that of the desmethyl-broflanilide (IC50 = 7.32 nM) to the SfrRDL1 receptor. The IC50 of isocycloseram to the SfrRDL2 receptor was 11.13 nM, which was obviously less than that of desmethyl-broflanilide, dieldrin, fipronil, fluxametamide. Compared with the SfrRDL2 receptor, the SfrRDL1 receptor exhibited higher sensitivity to GABAergic insecticides. The recombinant SfrGluCl receptor was successfully stimulated by l-glutamate; however, the currents were low and weakly inhibited by isocycloseram at 10 mu M. In conclusion, our results provided the theoretical basis for usage of GABAergic insecticides for controlling FAW.

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