Early Gonadal Development and Sex Determination in Mammal

文献类型： 外文期刊

第一作者： Xie, Yanshe

作者： Xie, Yanshe;Wu, Changhua;Li, Zicong;Wu, Zhenfang;Hong, Linjun;Xie, Yanshe;Wu, Changhua;Li, Zicong;Wu, Zhenfang;Hong, Linjun

作者机构：

关键词： gonadal development; sex determination; primordial germ cell; genes

期刊名称：INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES （ 影响因子：6.208； 五年影响因子：6.628 ）

ISSN：

年卷期： 2022 年 23 卷 14 期

页码：

收录情况： SCI

摘要： Sex determination is crucial for the transmission of genetic information through generations. In mammal, this process is primarily regulated by an antagonistic network of sex-related genes beginning in embryonic development and continuing throughout life. Nonetheless, abnormal expression of these sex-related genes will lead to reproductive organ and germline abnormalities, resulting in disorders of sex development (DSD) and infertility. On the other hand, it is possible to predetermine the sex of animal offspring by artificially regulating sex-related gene expression, a recent research hotspot. In this paper, we reviewed recent research that has improved our understanding of the mechanisms underlying the development of the gonad and primordial germ cells (PGCs), progenitors of the germline, to provide new directions for the treatment of DSD and infertility, both of which involve manipulating the sex ratio of livestock offspring.

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