Synthesis of substituted-amidine derivatives of avibactam and synergistic antibacterial activity with meropenem
文献类型： 外文期刊
第一作者： Sun, Jian
作者： Sun, Jian;He, Lili;Gao, Yuanyu;Zhai, Lijuan;Ji, Jingwen;Liu, Yuanbai;Ji, Jinbo;Mu, Yangxiu;Tang, Dong;Yang, Haikang;Iqbal, Zafar;Yang, Zhixiang;Ma, Xueqin
作者机构：
关键词： avibactam; beta-lactams; synergistic effect; amidation; amidines; 1, 6-diazabicyclo[3.2.1]octan-7-ones; sulfates
期刊名称：MENDELEEV COMMUNICATIONS （ 影响因子：1.786； 五年影响因子：1.517 ）
ISSN： 0959-9436
年卷期： 2021 年 31 卷 4 期
页码：
收录情况： SCI
摘要： New avibactam derivatives in which amide moiety is replaced by substituted amidine groupings were obtained in several steps, the key step having involved the conversion of 2-positioned cyano group of the 1,6-diazabicyclo[3.2.1]-octane framework into the amidine one. Synergistic antibacterial activity of the new compounds in combination with meropenem infers the agonistic effect of these derivatives against beta-lactamases.
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