Sodium Hypochlorite (NaClO) Disturbed Lipid Metabolism in Larval Zebrafish (Danio rerio), as Revealed by Lipidomics and Transcriptomics Analyses

文献类型： 外文期刊

第一作者： Wang, Wen

作者： Wang, Wen;Yang, Hua;Xiao, Xingning;Chen, Qu;Lv, Wentao;Ma, Lingyan;Xiao, Yingping;Fang, Chanlin;Jin, Yuanxiang

作者机构：

关键词： NaClO; lipid metabolism; lipidomic analysis; transcriptomic analysis; zebrafish

期刊名称：TOXICS （ 影响因子：4.1； 五年影响因子：4.6 ）

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年卷期： 2024 年 12 卷 10 期

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收录情况： SCI

摘要： Sodium hypochlorite (NaClO) has been widely utilized since the initial outbreak of coronavirus disease (COVID-19). The widespread use of NaClO means that it can directly enter aquatic ecosystems through wastewater discharge. In this study, we analyzed the expression of PPAR-gamma, FAS, and ACC1, which significantly increased in larval zebrafish following exposure to 300 mu g/L NaClO for 7 days. Additionally, we examined the effects of high concentrations of NaClO on zebrafish through non-targeted lipidomics and transcriptomics. A total of 44 characteristic lipid molecules were identified using non-targeted lipidomics; an absolute quantitative analysis revealed that the contents of these subclasses of lipids decreased significantly following exposure to 300 mu g/L NaClO for 7 days. The levels of triglyceride (TG), phosphatidylethanolamines (PE), and diglyceride (DG) were particularly affected. Transcriptomic analysis revealed that exposure to 300 mu g/L NaClO could significantly disrupt global gene transcription in larval zebrafish. Interestingly, more than 700 differentially expressed genes (DEGs) were identified, primarily associated with lipid metabolism and glycometabolism pathways. Overall, our study provided new insights into the toxicological effects of chlorine-containing disinfectants in aquatic organisms.

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