Iridoid glucosides from the leaves of Vitex negundo var. cannabifolia

文献类型： 外文期刊

第一作者： Sun, Jing

作者： Sun, Jing;Ma, Jiale;Li, Manman;Wang, Rongye;Liang, Naiyun;Zhao, Yunfang;Zheng, Jiao;Song, Yuelin;Tu, Pengfei;Huo, Huixia;Li, Jun;Sun, Jing

作者机构：

关键词： Verbenaceae; Vitex negundo var. cannabifolia; Iridoid glucoside; Stomachache; Human gastric epithelial cells

期刊名称：PHYTOCHEMISTRY LETTERS （ 影响因子：1.873； 五年影响因子：1.875 ）

ISSN： 1874-3900

年卷期： 2022 年 47 卷

页码：

收录情况： SCI

摘要： Five new iridoid glucosides, cannabifolisides A-E (1 - 5), together with nine analogues (6 - 14), were isolated from the leaves of Vitex negundo var. cannabifolia. Their structures were elucidated by spectroscopic data (NMR, UV, IR, and MS) analyses and comparison of their spectroscopic and physical data with the literature values. The protective effect of isolated compounds on human gastric epithelial cells were evaluated by measuring the enhanced cell viability of GES-1 cell insulted by TCA. Among these, compounds 4, 6, 8, 10, 12, and 14 remarkably increased the cell viability in a concentration-depend manner.

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