Temporal correlations of ferroptosis, inflammation and oxidative stress under acute ammonia exposure in brain tissue of yellow catfish (Pelteobagrus fulvidraco)

文献类型： 外文期刊

第一作者： Long, Xinran

作者： Long, Xinran;He, Kewei;Zhang, Muzi;Wang, Zhenlu;Dong, Xianghong;Shao, Jian;Gan, Lei;Jiang, Haibo;Long, Xinran;He, Kewei;Zhang, Muzi;Wang, Zhenlu;Dong, Xianghong;Shao, Jian;Gan, Lei;Jiang, Haibo;Li, Ming;Wang, Changan;Hu, Xiaojuan

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关键词： Ammonia toxicity; Ferroptosis; Inflammatory response; Oxidative stress; Pelteobagrus fulvidraco

期刊名称：COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY （ 影响因子：3.9； 五年影响因子：3.8 ）

ISSN： 1532-0456

年卷期： 2023 年 271 卷

页码：

收录情况： SCI

摘要： Ammonia is one of the most serious environmental stressors which severely affect fishery production. Ammonia toxicity to fish has a tight relationship with oxidative stress, inflammation and ferroptosis (a type of programmed cell death characterized by iron-dependent lipid peroxidation), but the temporal response of the above three in brain remains unclear. In the present study, yellow catfish were exposed to three concentrations of ammonia: low concentration (TA-N < 0.01 mg L-1, LA), middle concentration (TA-N 5.70 mg L-1, MA), high concentration (TA-N 28.50 mg L-1, HA) for 96 h. Brain was selected as target tissues for analysis. Results showed that ammonia stress resulted in firstly increased contents of hydroxyl radical at 1 h, total iron at 12 h, malondialdehyde at 48 h, respectively, and decreased contents of GSH at 3 h. The initial high expression levels of ferroptosis (GPX4, system xc- , TFR1) and inflammatory-related factors (NF-ƙB p65, TNF, COX-2, and LOX-15B), antioxidant enzymes genes (SOD and CAT) were observed at first hour upon MA or HA stress. Combining all, it suggested that brain fer-roptosis and inflammation were the first to be activated at the initial stage of ammonia stress, and then that provoked oxidative stress.

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