Temporal analysis the acetylation and cytokine levels of the Cronobacter muytjensii infection brain based on a bioluminescence mouse model

文献类型： 外文期刊

第一作者： Wang, Xiwen

作者： Wang, Xiwen;Chi, Hang;Li, Zhiping;Qu, Han;Xia, Zhiping;Li, Qianxue;Wang, Xiwen;Zhang, Yandong

作者机构：

关键词： Bioluminescence imaging; Lysine acetylation; Cytokine levels; LC-MS

期刊名称：JOURNAL OF NEUROIMMUNOLOGY （ 影响因子：3.478； 五年影响因子：3.438 ）

ISSN： 0165-5728

年卷期： 2021 年 360 卷

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收录情况： SCI

摘要： The present study aims to develop a bioluminescence Cronobacter muytjensii (C. muytjensii) infection animal model for use to evaluate the spatiotemporal acetylation and cytokine levels of brain. Frist, we cultured a luciferase expressing C. muytjensii that could be used for real-time monitoring in BALB/c mice. Then we performed a comparative acetylation analysis and cytokine levels analysis of the host's brain tissue. Further bioinformatic analysis studies have revealed that that some key acetylation proteins and inflammatory mediators involve in C. muytjensii infection. In this paper, the integration of bioluminescence imaging with Liquid Chromatography and Mass Spectrometry (LC-MS) based proteomics and quantitative analysis cytokine levels provide a systems-level understanding of infected brain response caused by C. muytjensii.

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