Effects of Microcystis on Hypothalamic-Pituitary-Gonadal-Liver Axis in Nile Tilapia (Oreochromis niloticus)

文献类型： 外文期刊

第一作者： Chen, Jiazhang

作者： Chen, Jiazhang;Meng, Shunlong;Chen, Jiazhang;Meng, Shunlong;Xu, Hai;Zhang, Zhen;Wu, Xiangyang

作者机构：

关键词： Microcystis; MC-LR; Brain; Hypothalamus-pituitary-gonadal-liver axis; Nile tilapia

期刊名称：BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY （ 影响因子：2.151； 五年影响因子：2.129 ）

ISSN： 0007-4861

年卷期： 2017 年 98 卷 4 期

页码：

收录情况： SCI

摘要： In the present study, Nile tilapia (Oreochromis niloticus) were used to assess the endocrine disruption potential of Microcytis aeruginosa. Male Nile tilapia were exposed to lyophilized M. aeruginosa or purified microcystin-LR (8.3 mu g/L) for 28 days. The levels of serum hormones (17 beta-estradiol and testosterone) and transcripts of selected genes in the hypothalamus-pituitary-gonadal-liver axis were analyzed. The results showed that serum hormones were significantly up-regulated, and transcripts of 13 genes (GHRH, PACAP, GH, GHR1, GHR2, IGF1, IGF2, CYP19a, CYP19b, 3 beta-HSD1, 20 beta-HSD, 17 beta-HSD1 and 17 beta-HSD8) were significantly altered after Microcytis exposure. These results indicate that fish reproduction can be altered in a Microcystis bloom-contaminated aquatic environment.

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