文献类型： 外文期刊
第一作者： Hu, Y.
作者： Hu, Y.;Li, B.;Wen, L.;He, K.;Hu, Y.;Li, B.;Wen, L.;He, K.
作者机构：
期刊名称：QJM-AN INTERNATIONAL JOURNAL OF MEDICINE （ 影响因子：3.21； 五年影响因子：3.452 ）
ISSN： 1460-2725
年卷期： 2018 年 111 卷 3 期
页码：
收录情况： SCI
摘要： Endotoxin is a significant contributing factor underlying the occurrence of fever, diarrhea, inflammation, edema, coagulation, shock and other syndromes associated with gram-negative bacterial infections. To date, there is no effective treatment for endotoxemia. The aim of this study was to characterize differentially expressed genes in sinomenine-treated and lipopolysaccharide (LPS)-induced endothelial cells by microarray analysis and to determine the potential pharmacological activity of sinomenine. The cultured cells of five treatment groups (n = 3) were collected. Participants: total RNA was extracted and subjected to Agilent Porcine 4 x 44 K whole genome microarray. Kyoto encyclopedia of genes and genomes and gene ontology software were applied to screen and analyze differentially regulated genes. The results showed that 723 differentially regulated genes were identified including 410 up-regulated genes and 313 down-regulated genes in therapy group vs. LPS group. Ten genes may be key controlled genes in the pathogenesis of LPS, including five up-regulated genes (ARG1, TLR2, IL1A, VCAM1, DKK3) and five down-regulated genes (HABP2, ID1, CHDH, GPX3, PTGFR), which primarily contribute to biological processes such as inflammatory response, vascular lesion, metabolic process and cell cycle. IL1A and FMO3 were considered as potent target genes. Global gene expression profile analysis showed that sinomenine might effectively be useful to regulate inflammatory responses as part of future anti-endotoxin therapies.
分类号：
- 相关文献
作者其他论文 更多>>
-
Molecular and transcriptomic analysis of the ovary during laying and brooding stages in Zhedong white geese (Anser cygnoides domesticus)
作者：Wang, Y.;Wang, S.;Zang, Z.;Li, B.;Huang, H.;Liu, G.;Zhao, X.
关键词：Reproductive hormones; follicles; apoptosis; mTOR, geese; ovary
-
Tissue Distribution of mtDNA Copy Number And Expression Pattern of An mtDNA-Related Gene in Three Teleost Fish Species
作者：Li, B.;Wang, H.;Zeng, X.;Liu, S.;Zhuang, Z.;Li, B.;Liu, S.;Jiang, C.;Zeng, X.;Zhang, T.
关键词：
-
ZOOPLANKTON COMPOSITIONS AND ITS RELATIONSHIP WITH SURVIVABILITY OF THE YANGTZE FINLESS PORPOISE IN THE NANJING YANGTZE DOLPHIN NATURE RESERVE
作者：Shi, K. J.;Wu, L.;Zheng, Z. R.;Li, X. Y.;Guan, X. Y.;Wang, R. T.;He, K.;Liu, K.;Liu, K.
关键词：taxonomic richness; density; fishing potential; heterogeneity; environmental factors
-
ZOOPLANKTON COMPOSITIONS AND ITS RELATIONSHIP WITH SURVIVABILITY OF THE YANGTZE FINLESS PORPOISE IN THE NANJING YANGTZE DOLPHIN NATURE RESERVE
作者：Shi, K. J.;Wu, L.;Zheng, Z. R.;Li, X. Y.;Guan, X. Y.;Wang, R. T.;He, K.;Liu, K.;Liu, K.
关键词：taxonomic richness; density; fishing potential; heterogeneity; environmental factors
-
Protein hydrolysates from silkworm (Bombyx mori) pupae protein treated with a novel neutral protease
作者：Herman, R. A.;Li, Z-N;Xie, C.;Wang, J-Z;Hu, Y.;Shittu, S.;You, S.;Wang, J.;You, S.;Wang, J.
关键词：enzymatic hydrolysis; silkworm (Bombyx mori) pupae protein; neutral protease; Stenotrophomonas maltophilia
-
Effect of pelleted alfalfa or native grass total mixed ration on the rumen bacterial community and growth performance of lambs on the Mongolian Plateau
作者：Zhou, Y. L.;Li, Y. C.;Chen, J. X.;Zhao, B.;Qian, C.;Li, B.;Liu, M.;Sun, L.;Cheng, Q. M.;Yu, H. R.;Wang, X. L.;Jia, Y. S.;Du, S.
关键词：Pelleted diet; Alfalfa; Native grass; Rumen; Microbiota
-
Analysis of Different Resistant Gossypium hirsutum Inoculated with Verticillium dahliae Infection by Small RNA and Degradome Sequencing
作者：Li, X. R.;Chen, F. Y.;Wang, J.;Hu, W. R.;Li, B.;Yang, Y.;Chen, X. J.;Chen, F. Y.;Ni, Z. Y.
关键词：Verticillium dahliae; Gossypium hirsutum; high-throughput sequencing; degradome sequencing; microRNA
