Recent Advances in Antibacterial and Antiendotoxic Peptides or Proteins from Marine Resources

文献类型： 外文期刊

第一作者： Wang, Zhenlong

作者： Wang, Zhenlong;Wang, Xiumin;Wang, Jianhua;Wang, Zhenlong;Wang, Xiumin;Wang, Jianhua

作者机构：

关键词： lipopolysaccharide; antibacterial activity; antiendotoxic activity; neutralization; marine resources

期刊名称：MARINE DRUGS （ 影响因子：5.118； 五年影响因子：5.951 ）

ISSN： 1660-3397

年卷期： 2018 年 16 卷 2 期

页码：

收录情况： SCI

摘要： Infectious diseases caused by Gram-negative bacteria and sepsis induced by lipopolysaccharide (LPS) pose a major threat to humans and animals and cause millions of deaths each year. Marine organisms are a valuable resource library of bioactive products with huge medicinal potential. Among them, antibacterial and antiendotoxic peptides or proteins, which are composed of metabolically tolerable residues, are present in many marine species, including marine vertebrates, invertebrates and microorganisms. A lot of studies have reported that these marine peptides and proteins or their derivatives exhibit potent antibacterial activity and antiendotoxic activity in vitro and in vivo. However, their categories, heterologous expression in microorganisms, physicochemical factors affecting peptide or protein interactions with bacterial LPS and LPS-neutralizing mechanism are not well known. In this review, we highlight the characteristics and anti-infective activity of bifunctional peptides or proteins from marine resources as well as the challenges and strategies for further study.

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