Preparation and characterisation of ginkgolide nanoparticles via the emulsion solvent evaporation method

文献类型： 外文期刊

第一作者： Jiang, Jianfang

作者： Jiang, Jianfang;Ao, Juan;He, Chunyang;Xiong, Jun;Zhao, Jiaqi;Liu, Jintao;You, Shengrong;Jiang, Hao

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关键词： nanoparticles; particle size; nanofabrication; organic compounds; nanomedicine; vacuum deposition; drugs; electrokinetic effects; surface morphology; ginkgolide nanoparticles; emulsion solvent evaporation method; cardiovascular disease treatment; cerebrovascular disease treatment; hydrodynamic diameter; surface zeta potential; surface morphology; nanomaterials; particle size; pharmacokinetics

期刊名称：MICRO & NANO LETTERS （ 影响因子：1.102； 五年影响因子：1.04 ）

ISSN： 1750-0443

年卷期： 2018 年 13 卷 5 期

页码：

收录情况： SCI

摘要： Ginkgolide is the first choice for treatment of cardiovascular and cerebrovascular diseases. However, its conventional dosage form (ginkgolide injection) can easily produce side effects and adverse reactions. Hence, developing a new, safe and efficient nanometre dosage form is imperative. Ginkgolide nanoparticles (GLNs) were prepared via the emulsion solvent evaporation method, and their mean hydrodynamic diameter, surface zeta potential, and surface morphology were characterised. The work studied four factors that were able to influence the properties of GLNs and discussed the preparation mechanism. The results showed that the prepared GLNs were nanomaterials. The optimum preparation conditions were with a W/O of 5.0, C-PVA of 6.0%, P of 250 W and T of 4.0 min. The GLN that was prepared under optimum conditions exhibited good dispersity and stability. Its surface zeta potential was -20.97 mV, single particle size was 20-50 nm, and the preparation yield was 73.51%. The pharmacokinetics of GLN was studied in detail, and the C-max and AUC(0 ->infinity) increased by 63.29 and 67.56%, respectively, compared with ginkgolide injection. This study lays a foundation for the research and development of new nano-dosage forms of ginkgolide and has an important value.

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