Computer Simulation Elucidates Yeast Flocculation and Sedimentation for Efficient Industrial Fermentation

文献类型： 外文期刊

第一作者： Liu, Chen-Guang

作者： Liu, Chen-Guang;Xia, Juan;Bai, Feng-Wu;Mehmood, Muhammad Aamer;Li, Zhi-Yang;Hao, Yue;Mehmood, Muhammad Aamer

作者机构：

关键词： DLA model; floc; flocculation; sedimentation; simulation; yeast

期刊名称：BIOTECHNOLOGY JOURNAL （ 影响因子：4.677； 五年影响因子：4.596 ）

ISSN： 1860-6768

年卷期： 2018 年 13 卷 5 期

页码：

收录情况： SCI

摘要： Flocculation plays an important role in the immobilized fermentation of biofuels and biochemicals. It is essential to understand the flocculation phenomenon at physical and molecular scale; however, flocs cannot be studied directly due to fragile nature. Hence, the present study is focused on the morphological specificities of yeast flocs formation and sedimentation via the computer simulation by a single floc growth model, based on Diffusion-Limited Aggregation (DLA) model. The impact of shear force, adsorption, and cell propagation on porosity and floc size is systematically illustrated. Strong shear force and weak adsorption reduced floc size but have little impact on porosity. Besides, cell propagation concreted the compactness of flocs enabling them to gain a larger size. Later, a multiple flocs growth model is developed to explain sedimentation at various initial floc sizes. Both models exhibited qualitative agreements with available experimental data. By regulating the operation constraints during fermentation, the present study will lead to finding optimal conditions to control the floc size distribution for efficient fermentation and harvesting.

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