Threshold level of Riemerella anatipestifer crossing blood-brain barrier and expression profiles of immune-related proteins in blood and brain tissue from infected ducks

文献类型： 外文期刊

第一作者： Li, Shengdou

作者： Li, Shengdou;Gong, Xiaowei;Chen, Qiwei;Zheng, Fuying;Ji, Guo;Liu, Yongsheng

作者机构：

关键词： Riemerella anatipestifer; Bacterial burden; Immune-related proteins; Blood; Brain

期刊名称：VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY （ 影响因子：2.046； 五年影响因子：2.217 ）

ISSN： 0165-2427

年卷期： 2018 年 200 卷

页码：

收录情况： SCI

摘要： Riemerella anatipestifer (R. anatipestifer) is a Gram-negative bacterium that crosses the blood-brain barrier (BBB: and causes meningitis with neurological symptoms in infected ducks. A threshold level of bacteremia must be reached before the BBB can be breached. In this study, the bacterial burden and expression profiles of immune. related proteins in blood and brain tissue samples from R. anatipestifer-infected ducks were investigated. The data showed that R. anatipestifer could cross the BBB with low-level bacteremia of 7.5 x 10(2) CFU/ml in infectec blood. Analysis of immune-related proteins revealed that IL-4, IL-17A, IL-17D, TLR3, TLR4, TLR7, and TGF-beta ir blood, as well as IL-1 beta, IL-2, IL-4, IL-17A, IL-17D, IL-17F, TLR3, TLR4, and TGF-beta in brain tissue were upre. gulated at an early stage in infection. The expression levels of Th1 and Th17-specific cytokines were significantly higher than those of Th2-specific cytokines, which indicated that mainly Th1 and Th17 immune responses were induced during R. anatipestifer infection.

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