Anthocidins A-D, New 5-Hydroxyanthranilic Acid Related Metabolites from the Sea Urchin-Associated Actinobacterium, Streptomyces sp HDa1

文献类型： 外文期刊

第一作者： Guo, Zhi-Kai

作者： Guo, Zhi-Kai;Wang, Rong;Chen, Shi-Quan;Chen, Fu-Xiao;Yang, Ming-Qiu;Liu, Tian-Mi

作者机构：

关键词： natural products; marine actinomycete; Streptomyces sp; anthocidin

期刊名称：MOLECULES （ 影响因子：4.411； 五年影响因子：4.587 ）

ISSN： 1420-3049

年卷期： 2018 年 23 卷 5 期

页码：

收录情况： SCI

摘要： Four new 5-hydroxyanthranilic acid related compounds, named anthocidins A-D (1-4), two known analogues n-lauryl 5-hydroxyanthranilate (5) and isolauryl 5-hydroxyanthranilate (6), together with benzamide (7), 3-hydroxy-4-methoxycinnamamide (8), and (3S-cis)-hexahydro-3-[(3,4-dihydroxyphenyl)methyl]pyrrolo[1,2-a]pyrazine-1,4-dione (9), were isolated from the fermentation broth of the marine-derived actinomycete, Streptomyces sp. HDa1, which was isolated from the gut of a sea urchin, Anthocidaris crassispina, collected from Hainan Island, China. The structures of these secondary metabolites were elucidated on the basis of their 1D and 2D-NMR and mass spectroscopic data, and anthocidin A was confirmed by single-crystal X-ray diffraction with Cu K radiation. Anthocidins A-D (1-4) feature an acetyl group substitution at the amino group and varying alkyl side chains at the carboxyl group of 5-hydroxyanthranilic acid, and compound 5 was isolated as a natural product for the first time. The cytotoxic and antibacterial activity of compounds 1-9 were evaluated.

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