文献类型： 外文期刊
第一作者： Guo, Zhi-Kai
作者： Guo, Zhi-Kai;Chen, Bi-Ting;Guo, Zhi-Kai;Chen, Bi-Ting;Chen, Bi-Ting;Chen, Dan-Dan;Deng, Xiao-Ling;Xu, Jing
作者机构：
关键词：
Mangrove; endophytic fungus;
期刊名称：JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH （ 影响因子：1.3； 五年影响因子：1.6 ）
ISSN： 1028-6020
年卷期： 2025 年
页码：
收录情况： SCI
摘要： Chemical investigation of the mangrove-derived fungus Phomopsis sp. DHS-11 led to the isolation of three new pyrone derivatives (1-3), and a new natural product (4). Their structures were identified by NMR spectroscopy and mass spectrometry. The configurations for the new pyrone derivatives were tentatively solved by comparison of 13C NMR data and analysis of the coupling constants and NOESY correlations. Compounds 2 and 3 exhibited significant cytotoxicity against HepG2 with IC50 values of 4.66 +/- 0.35 mu M and 6.07 +/- 0.48 mu M, respectively. Compound 3 showed moderate cytotoxicity against Hela cells with IC50 value of 20.2 +/- 4.93 mu M.
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