Role of innate immunity in pathophysiology of classical swine fever virus infection

文献类型： 外文期刊

第一作者： Goraya, Mohsan Ullah

作者： Goraya, Mohsan Ullah;Chen, Ye;Chi, Xiaojuan;Goraya, Mohsan Ullah;Ziaghum, Fozia;Chen, Shilong;Raza, Ali

作者机构：

关键词： Classical swine fever virus; Pathogenesis; Innate immunity; Immune evasion; Cellular immunity

期刊名称：MICROBIAL PATHOGENESIS （ 影响因子：3.738； 五年影响因子：3.663 ）

ISSN： 0882-4010

年卷期： 2018 年 119 卷

页码：

收录情况： SCI

摘要： Classical swine fever virus (CSFV) infection causes mild to severe diseases among pigs, depending on the age and immune status of the host and viral strains. CSFV targets various cells, including macrophages and conventional and plasmacytoid dendritic cells. Classical swine fever is one of the most devastating diseases of pigs which leads to high morbidity and mortality, and causes significant economic loss worldwide. In response to infection with CSFV, host innate immune system eliminates the virus by recognizing specific viral molecules via distinct cellular pattern recognition receptors. These receptors trigger downstream intracellular signaling pathways, which regulate the translocation and activation of transcription factors that control the production of cytokines and interferons (IFNs). In turn, these IFNs activate JAK-STAT signaling that governs the transcription of IFN-stimulated genes (ISGs) that play critical roles in antiviral immunity. However, CSFV has evolved different strategies to evade innate immune signaling and can establish persistent infection without being recognized by immune surveillance. In this review, we discuss the current understanding of host innate response to CSFV infection. We also summarize how CSFV evades innate immunity to establish its chronic infection.

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