Cytotoxic and Antibacterial Eremophilane Sesquiterpenes from the Marine-Derived Fungus Cochliobolus lunatus SCSI041401

文献类型： 外文期刊

第一作者： Fang, Wei

作者： Fang, Wei;Shi, Liqiao;Min, Yong;Fang, Wei;Wang, Jianjiao;Wang, Junfeng;Li, Kunlong;Lin, Xiuping;Yang, Bin;Liu, Yonghong;Zhou, Xuefeng;Tang, Lan

作者机构：

期刊名称：JOURNAL OF NATURAL PRODUCTS （ 影响因子：4.05； 五年影响因子：4.603 ）

ISSN： 0163-3864

年卷期： 2018 年 81 卷 6 期

页码：

收录情况： SCI

摘要： Three new eremophilane sesquiterpenes, dendryphiellins H-J (1-3), and three new phthalide natural products (4-6) were isolated from the marine-derived fungus Cochliobolus lunatus SCSI041401. Their structures including absolute configurations were determined by spectroscopic and calculated ECD analyses. Dendryphiellin I (2) showed cytotoxic and antibacterial activities against five cancer cell lines (IC50 1.4 to 4.3 mu M) and three bacterial species (MIC 1.5 to 13 mu g/mL), respectively. Dendryphiellin J (3), a rare naturally occurring aldoxime analogue, displayed cytotoxicities against ACHN and HepG-2 cells with IC50 values of 3.1 and 5.9 mu M, respectively. Further studies indicated that 3 induced apoptosis in ACHN cells in a dose- and time-dependent manner.

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