Amplification and adaptation of centromeric repeats in polyploid switchgrass species

文献类型： 外文期刊

第一作者： Yang, Xueming

作者： Yang, Xueming;Zhao, Hainan;Zhang, Tao;Zeng, Zixian;Zhang, Pingdong;Zhu, Bo;Han, Yonghua;Braz, Guilherme T.;Jiang, Jiming;Yang, Xueming;Zhao, Hainan;Zeng, Zixian;Jiang, Jiming;Zhang, Tao;Zhang, Pingdong;Han, Yonghua;Braz, Guilherme T.;Casler, Michael D.;Schmutz, Jeremy;Schmutz, Jeremy

作者机构：

关键词： cenH3 nucleosome; centromere; centromere evolution; satellite repeats; switchgrass (Panicum virgatum)

期刊名称：NEW PHYTOLOGIST （ 影响因子：10.151； 五年影响因子：10.475 ）

ISSN： 0028-646X

年卷期： 2018 年 218 卷 4 期

页码：

收录情况： SCI

摘要： Centromeres in most higher eukaryotes are composed of long arrays of satellite repeats from a single satellite repeat family. Why centromeres are dominated by a single satellite repeat and how the satellite repeats originate and evolve are among the most intriguing and long-standing questions in centromere biology. We identified eight satellite repeats in the centromeres of tetraploid switchgrass (Panicum virgatum). Seven repeats showed characteristics associated with classical centromeric repeats with monomeric lengths ranging from 166 to 187 bp. Interestingly, these repeats share an 80-bp DNA motif. We demonstrate that this 80-bp motif may dictate translational and rotational phasing of the centromeric repeats with the cenH3 nucleosomes. The sequence of the last centromeric repeat, Pv156, is identical to the 5S ribosomal RNA genes. We demonstrate that a 5S ribosomal RNA gene array was recruited to be the functional centromere for one of the switchgrass chromosomes. Our findings reveal that certain types of satellite repeats, which are associated with unique sequence features and are composed of monomers in mono-nucleosomal length, are favorable for centromeres. Centromeric repeats may undergo dynamic amplification and adaptation before the centromeres in the same species become dominated by the best adapted satellite repeat.

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