Orobanche cernua Loefling Attenuates Ultraviolet B-mediated Photoaging in Human Dermal Fibroblasts

文献类型： 外文期刊

第一作者： Gao, Wei

作者： Gao, Wei;Wang, Yu-shuai;Hwang, Eunson;Ngo, Hien T. T.;Yi, Tae-hoo;Qu, Zheng-yi;Wang, Ying-ping;Bae, Jahyun

作者机构：

期刊名称：PHOTOCHEMISTRY AND PHOTOBIOLOGY （ 影响因子：3.421； 五年影响因子：3.064 ）

ISSN： 0031-8655

年卷期： 2018 年 94 卷 4 期

页码：

收录情况： SCI

摘要： UV radiation is the primary cause of skin photoaging, which results in an increase in matrix metalloproteinases and degradation of collagen. Developing new natural antioxidant as photoprotective agents has become a popular area of research. Orobanche cernua Loefling is a parasitic plant that is rich in phenylethanoid glycosides (PhGs). This study investigated the photoprotective effects of the ethanolic extract of Orobanche cernua Loefling (OC) and its principal component acteoside on UVB-induced photoaging as well as their underlying molecular mechanisms in normal human dermal fibroblasts (NHDFs). Biological testing demonstrated that OC and acteoside possessed significant photoprotective activities, reducing MMP and IL-6 levels while improving type-I procollagen synthesis in UVB-irradiated NHDFs. Further study showed that the protective mechanisms were the improvement of transcription factor Nrf2-mediated antioxidant defensive system, suppression of MAPK/AP-1 and activation of the TGF-/Smad pathway. Together, our results suggested that OC might be a promising antiphotoaging agent against UV radiation-induced skin damage.

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