Streptoxamine, an unprecedented benzoisoindole-deferoxamine hybrid from the locust-derived Streptomyces sp HKHCa2
文献类型： 外文期刊
第一作者： Guo, Zhi Kai
作者： Guo, Zhi Kai;Wang, Rong;Chen, Fu Xiao;Liu, Tian Mi
作者机构：
关键词： Streptoxamine; Streptomyces sp HKHCa2; Locust; Antibacterial activity
期刊名称：FITOTERAPIA （ 影响因子：2.882； 五年影响因子：3.202 ）
ISSN： 0367-326X
年卷期： 2018 年 127 卷
页码：
收录情况： SCI
摘要： An unusual benzoisoindole-deferoxamine hybrid, streptoxamine (1), has been isolated from the ethyl acetate crude extract of the fermentation broth of a locust-associated actinomycete, Streptomyces sp. HKHCa2, which was isolated from an insect, Oxya chinensis. The structure of this secondary metabolite was elucidated on the basis of its one-dimension, two-dimension NMR, and mass spectroscopic data. This natural product features a hybrid pattern of a benzoisoindole with an "iron carrier" deferoxamine B through C-N linkage. Compound 1 showed weak antibacterial activity against the gram-positive bacteria, Staphylococcus aureus and Mycobacterium smegmatis.
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