Genome-wide association study of body weight in Wenshang Barred chicken based on the SLAF-seq technology

文献类型： 外文期刊

第一作者： Li, Fuwei

作者： Li, Fuwei;Han, Haixia;Lei, Qiuxia;Gao, Jinbo;Liu, Jie;Liu, Wei;Zhou, Yan;Li, Huimin;Cao, Dingguo;Li, Fuwei;Han, Haixia;Lei, Qiuxia;Gao, Jinbo;Liu, Jie;Liu, Wei;Zhou, Yan;Li, Huimin;Cao, Dingguo

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关键词： Body weight; Genome-wide association study; SLAF-seq; Wenshang Barred chicken

期刊名称：JOURNAL OF APPLIED GENETICS （ 影响因子：3.24； 五年影响因子：2.756 ）

ISSN： 1234-1983

年卷期： 2018 年 59 卷 3 期

页码：

收录情况： SCI

摘要： Chicken body weight (BW) is an economically important trait, and many studies have been conducted on genetic selection for BW. However, previous studies have detected functional chromosome mutations or regions using gene chips. The present study used the specific-locus amplified fragment sequencing (SLAF-seq) technology to perform a genome-wide association study (GWAS) on purebred Wengshang Barred chicken. A total of 1,286,715 single-nucleotide polymorphisms (SNPs) were detected, and 175,211 SNPs were selected as candidate SNPs for genome-wide association analysis using TASSEL general linear models. Six SNP markers reached genome-wide significance. Of these, rs732048524, rs735522839, rs738991545, and rs15837818 were significantly associated with body weight at 28 days (BW28), while rs314086457 and rs315694878 were significantly associated with BW120. These SNPs are close to seven genes (PRSS23, ME3, FAM181B, NABP1, SDPR, TSSK6L2, and RBBP8). Moreover, 24 BW-associated SNPs reached "suggestive" genome-wide significance. Of these, 6, 13, 1, and 4 SNPs were associated with BW28, BW56, BW80, and BW120, respectively. These results would enrich the studies on BW and promote the use of Chinese chicken, especially the Wenshang Barred chicken.

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