An intercross population study reveals genes associated with body size and plumage color in ducks

文献类型： 外文期刊

第一作者： Zhou, Zhengkui

作者： Zhou, Zhengkui;Fan, Wenlei;Xu, Yaxi;Guo, Zhanbao;Zhang, Yunsheng;Hu, Jian;Liu, Hehe;Liu, Dapeng;Jiang, Yong;Wen, Zhiguo;Xie, Ming;Zhang, Qi;Huang, Wei;Hou, Shuisheng;Li, Ming;Cheng, Hong;Xu, Yaxi;Chen, Weihuang;Zheng, Zhuqing;Jiang, Yu;Yuan, Zhengrong;Gao, Qiang;Liu, Yongming;Chen, Hua;Wang, Wen

作者机构：

期刊名称：NATURE COMMUNICATIONS （ 影响因子：14.919； 五年影响因子：15.805 ）

ISSN： 2041-1723

年卷期： 2018 年 9 卷

页码：

收录情况： SCI

摘要： Comparative population genomics offers an opportunity to discover the signatures of artificial selection during animal domestication, however, their function cannot be directly revealed. We discover the selection signatures using genome-wide comparisons among 40 mallards, 36 indigenous-breed ducks, and 30 Pekin ducks. Then, the phenotypes are fine-mapped based on resequencing of 1026 ducks from an F-2 segregating population generated by wild x domestic crosses. Interestingly, the two key economic traits of Pekin duck are associated with two selective sweeps with fixed mutations. A novel intronic insertion most possibly leads to a splicing change in MITF accounted for white duck down feathers. And a putative long-distance regulatory mutation causes continuous expression of the IGF2BP1 gene after birth which increases body size by 15% and feed efficiency by 6%. This study provides new insights into genotype-phenotype associations in animal research and constitutes a promising resource on economically important genes in fowl.

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